The invention relates to a process for the manufacture of salts of citalopram in high purity. By the careful selection of solvents and the careful manipulation of the pH value, citalopram salts may be isolated in the absence of 5-chlorocitalopram, 5-bromocitalo-pram, desmethyl-citalopram and 5-carobxyamide citalopram.

Process for the preparation of compounds of formula (I) wherein R is halogen, R.sub.1O.sub.1R.sub.1S(O).sub.n or (R.sub.1).sub.2NC(X)O; R.sub.1 is C.sub.1-C.sub.8alkly, aryl-C.sub.1-C.sub.8alkyl, C.sub.1-C.sub.8haloalkyl or aryl; n is 0, 1, 2 or 3; X is O or S; and R.sub.2 is hydrogen, C.sub.1-C.sub.4alkyl or C.sub.1-C.sub.4haloalkyl, in which process, in a solvent, (1) an aniline derivative of formula (IV) wherein R is as defined above, and R.sub.3 is C.sub.1-C.sub.5alkyl or C.sub.1-C.sub.5halo...

The present invention provides novel processes for the preparation of a cyclopentanone of Formula II and a lactone of Formula I, which are useful in the production of prostaglandins: ##STR00001## wherein Z, R.sub.2, R.sub.3, X.sub.1, X.sub.2, and are as defined in the specification.The invention also provides novel enantiomerically enriched compounds.

A new process is described for obtaining 5-cyanophthalide, which is an intermediate used for the synthesis of citalopram and its active enantiomer S(+) citalopram, both of which are known active ingredients commonly used for treating depression. The process involves starting from 5-carboxyphthalide which is converted into the corresponding acylochloride. The latter is reacted with hydroxylamine to produce the corresponding hydroxamyl phthalide, which is subsequently subjected to a dehydration re...

The present invention relates to substituted heterocyclic compounds and compositions comprising a substituted heterocyclic compound. The present invention also relates to methods for preventing or treating various diseases and disorders by administering to a subject in need thereof one or more substituted heterocyclic compounds. In particular, the invention relates to methods for preventing or treating cancer or an inflammatory disorder by administering to a subject in need thereof one or more s...

A compound of the formula ##STR1## wherein n, X, Y and Ar are as defined herein, useful in the treatment of a condition selected from the group consisting of arthritis, cancer, tissue ulceration, macular degeneration, restenosis, periodontal disease, epidermolysis bullosa, scleritis, and other diseases characterized by matrix metalloproteinase activity, AIDS, sepsis, septic shock and other diseases involving the production of TNF. In addition, the compounds of the present invention may be used i...

A cyclopropanecarboxylate represented by the formula, ##SPC1## Wherein R.sub.1 is hydrogen atom, methyl or ethyl group, R.sub.2 is methyl, ethyl, 2-methyl-1-propenyl or 2-methoxycarbonyl-1-propenyl group when R.sub.1 is hydrogen atom, or R.sub.2 is methyl or ethyl group when R.sub.1 is methyl or ethyl group, and R.sub.3 and R.sub.4 are respectively hydrogen atom, methyl or ethyl group, provided that the case where R.sub.1, R.sub.3 and R.sub.4 are simultaneously hydrogen atom is excluded, R.sub.5...

A gas burner for grills and the like has a fuel supply conduit communicating with a fuel receiving chamber having an open top and a plurality of open top flow passages extending therefrom. A cap member is securely positioned in spaced relation immediately above and in covering relation with upwardly facing edges of wall portions defining the open top of the receiving chamber and the flow passages extending therefrom to define a substantially continuous fuel exit slot therebetween whereby gas flo...

The subject invention provides novel compositions of biologically active linderazulene terpene compounds which can advantageously be used for treating cancer and stopping cell proliferation.

Benzofuran derivatives of the general formula: ##SPC1## And their pharmaceutically acceptable acid addition salts having superior pharmacological activities for diseases in circulatory system or peripheral nervous system, and method for the preparation of the said benzofuran derivatives.