A pharmaceutical composition for the treatment of immune-related diseases of ocular surface and the anterior segment of the eye. More specifically, the invention relates to a composition comprising tacrolimus in a pharmaceutically acceptable formulation, particularly a suitable local treatment formulation, such as eye drops and ointments. Also disclosed is a method for the treatment of immune-response related ocular diseases of the anterior segment of the eye and the eye surface, wherein the met...

Fluorescein and derivatives have use in the treatment of a disease of a living animal body, including human, which disease is responsive to the inhibition of the cystic fibrosis transmembrane conductance regulator chloride channels, for instance polycystic kidney disease and secretory diarrhoea.

Compounds of the formula having anti-tumor activity, wherein R.sub.1 and R.sub.2 are as described herein ##STR00001##

This invention relates to methods of inducing dephosphorylation of a hyperphosphorylated cell cycle regulatory protein in a tumor cell in which hyperphosphorylation of said protein contributed to cell transformation, the method comprising contacting the tumor cell with a procyanidin oligomer of five monomeric units connected via a C-4.fwdarw.C-8 linkage. Examples of such compounds are [EC-(4.beta..fwdarw.8)].sub.4-EC, and [EC-(4.beta..fwdarw.8)].sub.3-EC-(4.beta..fwdarw.8)-C, wherein EC is epica...

A water soluble, essentially water-free ubichinon concentrate is described, which contains an emulsifier with an HLB value between 9 and 16, ubichinon Q.sub.10, as well as a light oil containing triglyceride. Furthermore, a method for producing the concentrate is described.

Carcinoma is treated in a patient by administration of Rhodamine-123 (Rh-123) orally or by intravenous injection of a treatment solution of Rh-123, ethyl alcohol, dextrose, and water in an amount sufficient to effect in vivo destruction of cancer cells. The treatment solution is made by mixing a stock solution of Rh-123 in a solution of 95% ethyl alcohol and 5% water (by volume) with a solution of 5% (by weight) dextrose in water. For prostate cancer, treatment is controlled by measuring the lev...

A substance with sedative effect comprises a therapeutically effective amount of a gamma-pyrone such as comenic acid, meconic acid, chelidonic acid, and alike in a pharmaceutically acceptable carrier. When administered at a daily dosage of between 5 and 200 mg of active ingredient per kilogram of a body weight of a patient, the substance can be used to treat various neurotic disorders such as insomnia, anxiety, neurosis, depression as well as withdrawal symptoms for drug addiction patients, espe...

The subject invention provides novel compositions of biologically active polyketide compounds that can advantageously be used in blocking cellular proliferation and treatment of cancer.

This invention relates to benzopyran derivatives of the formula (1) or the formula (2) wherein R.sup.1 and R.sup.2 represent independently of each other hydrogen atom or C.sub.1-6alkyl group, R.sup.3 represents hydroxyl group or C.sub.1-6 alkylcarbonyloxy group, R.sup.4 represents hydrogen atom or C.sub.1-6 alkyl group, R.sup.5 represents C.sub.1-6 alkyl group substituted with C.sub.6-14 aryl group or heteroaryl group, R.sup.6 represents C.sub.1-6 alkyl group, C.sub.1-6 alkoxy group, halogen ato...

The present invention generally relates to compounds and compositions useful for the modulation of ligase activity. The invention further relates to Compounds of the Invention, compositions thereof, and methods for treating or preventing cancer, a neoplastic disorder, acute or chronic renal failure, an inflammatory disorder, an immune disorder, a cardiovascular disease, an effect of aging or an infectious disease comprising administering an effective amount of a Compound of the Invention. The in...