Alkoxy - substituted 3-(aminophenyl)-coumarins are prepared by hydrogenation of the corresponding nitrophenylcoumarin derivative in the presence of Raney nickel or a noble metal catalyst. The novel amino compounds are useful, by virtue of fluorescence in ultraviolet light, as optical brighteners, as ultraviolet light filters, in the preparation of polyureas and photoresist polymers. Also, the novel amino compounds can be phosgenated to yield the corresponding isocyanates.

This disclosure describes unique chemical structures for use as solid or concentrated chemical precursors to the production of peroxy acids when combined with hydrogen peroxide or a hydrogen peroxide precursor such as percarbonates or perborates. Peroxy acids (peracids) such as peroxyacetic acid are used currently to disinfect medical equipment such as endoscopes and related items. It has been discovered that these structures are not currently listed in Chemical Abstracts and do not appear to be...

The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors characterized by specific structural and physicochemical features. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting HIV-1 and HIV-2 protease activity and co...

A compound of the general formula (I) or (II) wherein X is O, NR.sub.4 or S and R.sub.1-R.sub.8 are as defined in the specification ##STR00001##

Compounds corresponding to formula I: ##STR00001## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 have the meanings given in the description; a process for the preparation of these compounds; intermediate products used to prepare such compounds, and pharmaceutical compositions containing such compounds.

Safe, effective first-pass inhibiting compounds and citrus-derived substances are provided. Formulations containing the compounds are also provided as are methods for inhibiting the first pass effect.

This present invention provides materials for use as solid or concentrated chemical precursors for the production of organic peroxy acids (peracids). Organic peroxy acids are formed using a precursor according to the invention when they are combined with hydrogen peroxide or a hydrogen peroxide precursor such as a percarbonate or a perborate in aqueous medium. Organic peroxy acids, such as peroxyacetic acid, are used currently to disinfect medical equipment such as endoscopes and related items.

Novel substituted chroman derivatives and intermediate compounds, compositions containing same, methods for their preparation and uses thereof as therapeutic agents particularly as anti-cancer and chemotherapeutic selective agents are described.

Processes for the preparation of biologically active chromanones are disclosed, including processes for the preparation of intermediates useful in the preparation of the biologically active chromanones. The chromanones and the intermediates disclosed herein may be useful for a variety of therapies, including the treatment of various cancers and the treatment of inflammation and inflammation related disorders.

The present invention provides an economically and industrially superior simple process that enables the selective production of an aromatic heterocyclic monoboron compound and aromatic heterocyclic diboron compound at a satisfactory yield and in a desired ratio by reacting an aromatic heterocyclic compound and a boron compound in a single step under mild conditions while changing only the charged ratios of the raw materials.The present invention provides a production process of a heteroaryl mon...