The present invention relates to adjuvant compositions which are suitable to be used in vaccines. In particular, the adjuvant compositions of the present invention comprises a saponin and an immunostimulatory oligonucleotide, optionally with a carrier. Also provided by the present invention are vaccines comprising the adjuvants of the present invention and an antigen. Further provided are methods of manufacture of the adjuvants and vaccines of the present invention and their use as medicaments. ...

The present invention relates to dermal vaccine formulations, designed for targeted delivery of an immunogenic composition to a dermal compartment of skin including the intradermal and epidermal compartments. The dermal vaccine formulations of the invention comprise an antigenic or immunogenic agent, and at least one molecule, e.g., a chemical agent, which enhances the presentation and/or availability of the antigenic or immunogenic agent to the immune cells of the intradermal compartment or epi...

A valve assembly is disclosed that provides for complete or partial fluid pressure balancing across the valve, and can be used for reducing valve actuation forces in order to employ electric actuation. The valve assembly includes a valve housing having a valve chamber, a flow passageway, and a piston chamber. A valve member is disposed in the valve housing and is movable along a valve axis. The valve member is subjected to a first pressure, which urges the valve in a first direction. To countera...

The infusion of TIL586 along with interleukin-2 (IL-2) into the autologous patient with metastatic melanoma resulted in the objective regression of tumor. A gene encoding a tumor antigen recognized by TIL586 was previously isolated and shown to encode gp75 or TRP-1. The present invention relates to the identification of a second tumor antigen recognized by a HLA-A31 restricted CTL clone derived from the TIL586 cell line. This antigen derived from the TRP-2 protein tumor antigen and peptides ther...

A washer has a body having an axis and provided with a first bearing face surface located at one axial side and adapted to cooperate with a nut, a second bearing face surface located at an opposite axial side and adapted to cooperate with an object, at least one third turning resistant surface adapted to cooperate with a thread of the bolt, the body having at least one resistive point arranged so that when the nut is turned and turns the bolt the body of the washer stops the bolt from turning an...

A system and method for electronically controlling the displacement of hydraulic pumps, IHTs or HSTs. The IHT and HST includes a hydraulic transmission mounted within the casing that includes a rotatable hydraulic pump in fluid communication with a rotatable hydraulic motor and a moveable swash plate cooperable with the rotatable hydraulic pump for controlling the speed and direction of rotation of the rotatable hydraulic motor. The rotation of the hydraulic motor is used to drive an axle shaft....

The invention provides an auxiliary fastening device for assisting a cable being fastened onto a surface of an electronic apparatus, including a first connector disposed on the surface of the electronic apparatus. The cable includes a second connector adapted to the first connector and a plurality of signal lines coupled to the second connector. The auxiliary fastening device, according to the invention, includes a base having a top surface and a fastening member having a lower surface. When the...

The present invention provides methods for inducing an antigen-specific immune response by administering allogeneic antigen-presenting cells to a subject. In another aspect, an effective amount of autologous antigen-presenting cells are co-administered to a subject.

A container closure includes a shell attachable to a container around a container opening thereof. The shell has a shell opening in fluid communication with the container opening when the shell is attached to the container. A tip is received on the shell movable between a closed position sealing the shell opening and an open position. A cover is releasably attached to the shell in a manner indicative of the tip being positioned in the closed position when the cover is attached to the shell. The ...

A wheel assembly for a material handling cart includes a wheel hub having first and second openings in first and second hub faces, each concentric with and extending along a central axis of the wheel hub. First and second ball bearings are located in the openings. Inner rings of the bearings are wider than the outer rings, and the inner rings contact one another. The outer rings are separated by, and are in contact with, a hub member. First and second bearing sleeves in the first and second open...