The invention enables reduction of catalyst in producing tetrafluorobenzonitrile by decyanation of one cyano group of tetrafluorodicyanobenzene by using a synthetic zeolite, particularly Zeolite 3A, 4A or 5A, in the reaction. Therefore, the invention provides an industrially useful process capable of producing tetrafluorobenzonitrile, a useful agrochemical and drug intermediate, by hydrogenolysis of tetrafluorodicyanobenzene to decyanate one cyano group with the use of catalyst in small amounts.

A process for preparing halongenated derivatives of benzonitrile by a direct vapor phase reaction of a halogen and benzonitrile in an open tube. Halogenated benzonitriles are useful as fungicides.

Fluorobenzonitriles are prepared by reacting their corresponding chlorobenzonitriles with at least one alkali metal fluoride, in an aprotic solvent reaction medium, in the presence of at least one tertiary amine sequestering agent having the structural formula:

Novel ethynylindenyl compounds and derivatives are described. Their use in the treatment of inflammation is also disclosed.

The disclosure relates to novel 3,4-disubstituted-branched-chain-acylanilides, processes for their manufacture and pharmaceutical compositions containing them. The compounds possess anti-androgenic activity. Representative of the compounds disclosed is 3,4-dicyanoisobutyranilide.

The disclosure relates to novel 3,4-disubstituted-branched-chain-acylanilides, processes for their manufacture and pharmaceutical compositions containing them. The compounds possess anti-androgenic activity. Representative of the compounds disclosed is 3,4-dicyanoisobutyranilide.

A one step method of converting 2,6-disubstituted benzaldehydes to 2,6-disubstituted benzonitriles which comprises heating benzaldehyde in the presence of a hydroxylamine and a dehydrating agent for about 1 to 40 hours at a temperature of 110.degree.-250.degree. and then separating out the resultant 2,6-disubstituted benzonitrile.

A process for the production of a fluorobenzonitrile wherein a chlorobenzonitrile having a chlorine atom in an ortho- or para- position with respect to a nitrile group is heated with an alkali metal fluoride at a temperature between 200.degree. and 250.degree. C., in the presence of sulpholane.

In a process for producing a nitrile compound from a corresponding aldehyde exhibited by the general formula (I) and a hydroxylamine inorganic acid salt or from an aldoxime exhibited by the general formula (II), (in the general formulas shown hereinabove, R.sup.1 represents an aryl group having 6 to 9 carbon atoms and R.sup.2 represents an alkyl or alkenyl group having 1 to 9 carbon atoms or an aryl group having 6 to 9 carbon atoms), a process, wherein water produced in the reaction is azeotropi...

A novel process for industrially producing an aromatic nitrile compound represented by the following general formula (3): ##STR00001## characterized in that one of an aromatic hydroxymethyl compound, an aromatic alkoxymethyl compound and an aromatic aldehyde compound, all represented by the following general formula (1): ##STR00002## or a mixture thereof is reacted with an oxidized bromine compound represented by the general formula (2) MBrO.sub.m (2) in the presence of an acid catalyst and eith...