A method of synthesizing 7-silyl camptothecins and 7-silyl homocamptothecins includes the step of mixing a camptothecin or a homocamptothecin having hydrogen at the C7 position with a silyl radical generator and a silyl radical precursor under conditions to generate a silyl radical. SiR.sup.1 R.sup.2 R.sup.3 wherein R.sup.1, R.sup.2 and R.sup.3 are independently a C.sub.1-10 alkyl group, a C.sub.2-10 alkenyl group, a C.sub.2-10 alkynyl group, an aryl group, --(CH.sub.2).sub.m R.sup.11 or SiR.sup...

This invention relates to novel derivatives of camptothecin, and will, particularly to derivatives having a substitution at the C-7 position, or at one of the C-9, C-10, C-11 or C-12 positions, or to disubstituted derivatives having a first substitution at C-7 and a second at one of C-9, C-10, C-11 or C-12. The invention also includes methods of using the compounds as Topoisomerase I inhibitors to treat patients with cancer. The invention also includes pharmaceutical formulations which consist o...

The present invention is directed to the synthesis and characterization of compounds having the formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8 and R.sub.9 are each independently selected from the group consisting of H, OH, OR', SH, SR', SOR', SO.sub.2 R', NO.sub.2, NH.sub.2, NHR', N(R').sub.2, NHC(O)R', CN, halogen, .dbd.O, C(.dbd.O)H, C(.dbd.O)R', CO.sub.2 H, CO.sub.2 R', C.sub.1 -C.sub.12 alkyl, C.sub.2 -C.sub.12 alkenyl, C.sub.2 -C.sub.12 alky...

In active range finder apparatus wherein an object to be inspected is illuminated by a laser source and light reflected by the object is detected in an imaging photosensor, a system is provided for increasing the dynamic range of the apparatus. This system provides for integrating over each of a series of measuring time periods light reflected from a window of the photosensor and hence proportional to the light received by such photosensor. When such integrated light exceeds a predetermined amou...

The invention is a method for increasing the resolution of LADAR data. In one embodiment of the invention wherein the LADAR data is generated from a split beam laser signal transmitted at a given elevation scan rate and a given azimuth scan rate, the method includes reducing the elevation scan rate by which the laser signal is transmitted by a factor of n; and reducing the azimuth scan rate by which the laser signal is transmitted by a factor of m; wherein n and m are integers greater than 1.

An optical backscatter filter (10) for use with continuous wave laser radar systems. The filter removes undesired frequency components corresponding to optical backscatter from a received input signal (12) to extract a desired return signal (32) associated with a target. The received signal (32) is processed optically, requiring only an electronic notch filter (24) and one electronic mixer (30) to finally extract the desired return signal (32).

In a method for locating an object such as a target for firing simulation in which the echo of a radiation beam emitted in the direction of the object and reflected back from the object is detected in the form of an electric signal, the signal is subjected to a correction treatment in order to compensate for variations in detection sensitivity as a function of the distance of the object. The signal treatment primarily consists in imposing on the signal a variable minimum threshold or a constant ...

For obtaining distance information between an image pickup device (10) and an object (11) illuminated by a monochromatic beam selected by a diffraction grating (18) from an optical beam generated by an optical beam generator (27), a distance information obtaining device comprises an activating device (33) for simultaneously activating the beam generator and the image pickup device a predetermined time duration so that the optical beam generator generates an optical beam while activated and so th...

In the photoelectric conversion method and apparatus applicable to displacement sensors irradiating light to objects and sensing the distances to the objects, distance-determining type photoelectric sensors etc., the method and apparatus arrange n (n>2) light-receiving elements in a predetermined direction, and divide each photoelectric current I1, I2, . . . , In of each light-receiving element in predetermined ratios k1 to 1-k1, k2 to 1-k2, . . . , kn to 1-kn; and lead the divided photoelect...

Non-naturally occuring dynemicin analogs are provided, which are useful as DNA cleaving agents, cytotoxic agents, and/or anti-tumor compounds. Methods of making dynemicin analogs are also provided.