Compounds of the formula IV: ##SPC1## wherein X is selected from the group consisting of sulfur and ##SPC2## Wherein R.sub.1 is selected from the group consisting of hydrogen, alkyl of one to three carbon atoms, inclusive; ##SPC3## In which n is 2 or 3, R.sub.7 and R.sub.8 are hydrogen or alkyl as defined above, or together ##SPC4## Is pyrrolidino, piperidino or N-methylpiperazino; wherein R.sub.3 and R.sub.4 are selected from the group consisting of hydrogen, fluoro, chloro, bromo, or alkyl, de...

Mammals are anesthetized by administration of 2-arylalkyloxy benzamides. When administered, the 2-arylalkyloxy benzamides of this invention are useful for the production of anesthesia, such as local anesthesia, in mammals. When administered intramuscularly, compounds of this invention show significant anesthesia when compared with xylocaine. Again, intradermic injections of 0.2 ml. of a solution of such a compound in concentrations varying from 0.1 to 1.25 mg./ml. effect suppression of platysma ...

Novel penicillins having the formula ##SPC1## Are disclosed along with methods for the preparation of these compounds.

Disclosed are compounds of the class of furo[3,2-c] pyridines substituted at the 4- position by an amino function bearing a hydroxy-alkyl nitrate moiety, e.g., 4- [4-(2-hydroxyethyl)-1-piperazino]-furo[3,2-c]pyridine nitrate. The compounds have pharmacological activity in animals and are useful, for example, as anti-anginal agents. Also disclosed are the corresponding hydroxy intermediates which are useful in preparation of the nitrates and also as anti-anginal agents or as agents in the treatme...

Compounds containing a cephem nucleus are prepared by heating a 1-oxide of a Schiff base of 6-aminopenicillanic acid. These cephem compounds are useful as intermediates in the preparation of physiologically active cephalosporins.

.beta.-[Benzo(b)thienyl-3] propionic acid derivatives in the form of their amino esters (and salts thereof) are prepared. These compounds have spasmolytic, vasodilatatric, antiserotonic and local anaesthetic activity.

Pharmaceutical compositions containing as active ingredients compounds of the formula ##SPC1## Wherein R.sub.1 is hydrogen, straight or branched alkyl of 1 to 6 carbon atoms, monohydroxy-(alkyl of 1 to 6 carbon atoms), or ##SPC2## Where R.sub.4 and R.sub.5 are each straight or branched alkyl of 1 to 4 carbon atoms, or, together with each other and the nitrogen atom to which they are attached, morpholino, pyrrolidino, piperidino or N'-methyl-piperazino, R.sub.2 is hydrogen or alkyl of 1 to 3 carb...

Acyl derivatives of 4-hydroxy-2H-1-benzothiopyran-3-carboxamide 1,1-dioxide having the following structural formulas are disclosed: ##SPC1## Wherein R.sub.1 and R.sub.2 are hydrogen, alkyl, aryl, aralkyl, alkoxy, halogen, cyano, nitro, trifluoromethyl, and the like. These compounds are useful as anti-inflammatory agents.

Novel 6-amino-9-(substituted benzyl) purines are prepared by allowing an appropriate substituted benzyl halide, e.g., a substituted benzyl chloride, to react with adenine under the appropriate conditions. Oxidation of the resulting purine derivatives yields the corresponding N.sup.1 -oxides. These compounds, i.e., both the purine derivatives and the N.sup.1 -oxides thereof, have anti-coccidial activity and are useful for controlling cecal and/or intestinal coccidiosis when administered in minor ...

Compounds of the formula ##SPC1## Wherein R.sup.1 is CN or an alkoxycarbonyl group, R.sup.2 is NH or an oxo group, n is an integer of from 3 to 6 inclusive and the ring A may be substituted by lower alkyl or phenyl are produced by reacting a compound of the formula ##SPC2## Wherein R.sup.3 is an alkoxyl or amino group and n and ring A are as defined above with a compound of the formula ##SPC3## Wherein R.sup.4 is an alkoxyl or amino group, R.sup.5 is CN or an alkoxycarbonyl group and R.sup.1 is ...