A method for inducing cell death in neoplastic cells, includes the step of administering a compound of formula I or a pharmaceutically acceptable salt thereof, as a primary chemotherapeutic agent or substantially contemporaneously with chemotherapy, to a patient having multidrug-resistant neoplastic cells, in an amount sufficient to induce cell death in the neoplastic cells: ##STR1## where R.sup.1 is hydroxyl, C1-4 alkoxyl, C1-4 alkylcarboxyloxymethoxyl, phenyl C1-2 alkylamino group, 2,5-pyrroli...

A method for inducing cell death in neoplastic cells, includes the step of administering a compound of formula I or a pharmaceutically acceptable salt thereof, as a primary chemotherapeutic agent or substantially contemporaneously with chemotherapy, to a patient having multidrug-resistant neoplastic cells, in an amount sufficient to induce cell death in the neoplastic cells: ##STR1## where R.sup.1 is hydroxyl, C1-4 alkoxyl, C1-4 alkylcarboxyloxymethoxyl, phenyl C1-2 alkylamino group, 2,5-pyrroli...

Novel [1-(1,4-benzodioxan-2-yl)-4-(4-aminopyrimidin-2-yl]piperazines having the general formula ##STR1## wherein: R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are independently selected from the group consisting of hydrogen and lower alkyl; X and Y are independently selected from the group consisting of hydrogen, lower alkyl, lower alkoxy or halogen; and n is either 0, 1 or 2 and the pharmaceutically acceptable acid addition salts thereof are useful as anti-depressants.

Fungicidally effective 2-amino pyrimidines bearing in the 6-position a carboxyl- or sulphonyl-esterified hydroxy or mercapto group; or salts thereof.

Pyrimidine ethers and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, infl...

New derivatives of cyanoaryl (or cyanoheteroaryl)-carbonyl-piperazinyl-pyrimidines (I), where R.sub.1 represents an OR.sub.3 radical, where R.sub.3 represents a radical derived from a saturated hydrocarbon, with a linear or branched chain of 1 to 4 carbon atoms, and R.sub.2 represents a phenyl radical substituted at least by one cyan radical (--C.ident.N), or a radical of a heteroaromatic ring of 5 or 6 members substituted at least by one cyan radical (--C.ident.N); and their physiologically acc...

Disubstituted piperazines of the formula: ##STR1## in which: n is 1 or 2, X is oxygen and Y is sulfur or sulfonyl or X and Y are both sulfur or sulfonyl, and Het is a 5- or 6-membered heterocyclic radical having from 1 to 3 hetero atoms inclusive selected from nitrogen and sulfur and optionally substituted by one or more alkyl each having from 1 to 5 carbon atoms inclusive. These compounds may be used as medicines, especially in the treatment of central nervous system disorders and Parkinson's d...

Compounds of Formula (IC) that act as 5-HT receptor ligands and their uses in the treatment of diseases linked to the activation of 5-HT.sub.2 receptors in animals are described herein ##STR00001## .

New 1-piperazinylpyrimidine derivatives, preparation thereof and application thereof in therapeutics and cosmetics. New compounds derived from 1-piperazinylpyrimidine derivatives, and their application in therapeutics and cosmetics, corresponding to the general formula: ##STR1## in which R represents an alkoxycarbonyl group containing from 1 to 3 carbon atoms in the alkoxy chain or alternatively a furoyl group, n being 0 or 1, and their addition salts with cosmetically or pharmaceutically accept...

A compound represented by the formula: ##STR00001## (wherein, R.sup.1 and R.sup.2 are the same or different and each represents a hydrogen atom, hydrocarbon group or heterocyclic group, or R.sup.1 and R.sup.2 may form, together with the adjacent carbon atom, a 3 8 membered iso- or heterocyclic group, R.sup.3 represents a cyclic group, a hydroxy group, a mercapto group that may have oxo, or an amino group, R.sup.4 represents a hydrogen atom, a hydrocarbon group, a hydroxy group, a mercapto group ...