Chromanols of the formula (II) ##SPC1## wherein R.sub.1 is a non-aromatic hydrocarbon group of 1-20 carbon atoms, R.sub.2 is a hydrocarbon group of 1-20 carbon atoms optionally substituted by a halogen atom and X is an optionally salted, etherified or acylated hydroxyl group, and N-oxides, acid-addition and quaternary salts thereof are shown to have anti-hypertensive activity. Their preparation and compositions containing them are described.

The present invention relates to a pharmaceutical composition comprising: (a) a compound of the formula ##STR1## wherein R.sup.1 and R.sup.2 are as defined below; and (b) isosorbide 5-mononitrate or isosorbide 2-mononitrate or glycerol trinitrate or glycerol 1-mononitrate or glycerol 2-mononitrate: and, optionally (c) a pharmaceutically acceptable carrier. The composition is useful in the prevention and treatment of cardiovascular diseases, and is especially useful in the prevention and treatmen...

The use of the compound 2-(6-cyano-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)pyridine-1-oxide represented by the formula ##STR1## as well as pharmaceutically acceptable salts, as topical agents to promote hair growth is disclosed.

Benzothiophene analogs useful to treat herpes viral infections, particularly cytomegalovirus, are provided. These antiviral agents have the structural formula (I) ##STR1## wherein R and R.sup.1 are as defined herein, and may be in free base or acid addition salt form. Pharmaceutical compositions are provided containing the antiviral agents, as are methods of treating herpes-infected individuals.

An expandable trailer for highway trucks having a first frame attachable to a driving vehicle and a second frame attached to the first frame and to which the trailer wheels are journaled. The second frame comprises two transversely disposed girders which are transversely slidable with respect to the first frame, such girders being attached to each other telescopically in the transverse direction. Piston and cylinder means are attached to the second frame and are adapted transversely to expand an...

Compounds of formula (I'), and compositions containing them: ##STR1## wherein n is 1, 2 or 3, each R.sub.1 independently represents a halogen atom; a hydroxy, carboxyl or C.sub.1-4 alkyl group, a C.sub.2-4 alkenyloxy, phenyl or phenyl-C.sub.1-4 alkoxy group which may be optionally substituted by one or more halogen atoms; an amino, mono- or dialkyl-amino, morpholino or piperazino group; a group of formula --S(O).sub.x R.sub.a where x is 0, 1 or 2 and R.sub.a is a C.sub.1-4 alkyl group; or a C.su...

Hypertension can be treated with a nicotinate of chroman of the formula: ##STR1## WHEREIN N IS AN INTEGER OF FROM 0 TO 3, R.sub.1 stands for ##STR2## and R.sub.2 stands for --CH.sub.3 or ##STR3## with the proviso that when R.sub.1 is ##STR4## R.sub.2 is --CH.sub.3 and the case where both of R.sub.1 and R.sub.2 stand for --CH.sub.3 is excluded.

The current invention provides a method useful for inhibiting the loss of bone using 6-hydroxy-2-(4-hydroxyphenyl)-benzo(B)thien-3-yl-4[2-(piperidin-1-ethoxyph enol]methanone hydrochloride.

A method of treating inflammation which comprises topically administering to the affected area a compound of the formula ##STR1## or a pharmaceutically acceptable addition salt thereof, is described.

Compounds having both calcium antagonist and antioxidant activity are disclosed. The compounds are useful in preventing or alleviating damage to tissues at the cellular level. Methods of treatment which employ these properties of the compounds and corresponding pharmaceutical compositions are also disclosed.