Mixtures of certain 2,2-disubstituted-1,3-propanediol-dicarbamates, such as meprobamate, and certain 1-substituted-2,2-dialkyl-1,3-propanediol monocarbamates produce a narcosis effect when administered to mammals. A greater narcosis would be obtained by such a mixture than that expected by the sum of the effects of each component of such mixture.

Synergistic arthropodicidal compositions comprising a carbamate, carboxylic acid ester or phosphate ester and an .alpha.-substituted-3,4-methylenedioxyphenylacetonitrile of the formula ##STR1## in which R represents hydrogen, alkyl, alkenyl, halogen or nitro, R.sup.1 represents alkyl or hydrogen, and R.sup.2 represents aralkyl, alkyl, alkenyl or cycloalkyl or may represent hydrogen, provided that R represents alkyl, alkenyl or nitro, or R.sup.1 and R.sup.2 together represent an alkylene radical.

A method for treating hyperglycemia in a mammal which comprises administering to said mammal a hyperglycemic amount of a derivative of 4-(((1,3-benzodioxol-5-yl)methyl)amino)benzoic acid or a pharmaceutically-acceptable salt thereof.

2-alkyl-5,6 alkylenedioxyindenes and indane-1-di- or tri- alkylammonium salts are useful as calcium antagonists, for example in arrhythmia. The compounds are prepared from the known corresponding 2,5,6-substituted indene-1-1dimethylammonium salts by alkylation and/or hydrogenation.

A compound of the formula (I) may be prepared by known methods and may be used in the treatment of pain, inflammation or pyresis in mammals, by administration of the compound alone or in a pharmaceutical formulation suitable for administration to a mammal in need thereof. ##STR1##

This invention relates to treatments for arthritis and cast dermatitis by the administration to patients of 3,4-methylenedioxyamphetamine and its non-toxic addition salts.

Aromatic carboxylic amides of the general formula: ##STR1## wherein each of R.sub.1 and R.sub.2 is a hydrogen atom or an alkyl group having 1-4 carbon atoms, R.sub.3 and R.sub.4 are hydrogen atoms or together form another chemical bond, each X is a hydroxyl group, a halogen atom, an alkyl group having 1-4 carbon atoms and an alkoxyl group containing 1-4 carbon atoms, and may be the same or different, and n is an integer of 1-3, provided that when two Xs are alkyl or alkoxyl groups, the alkyl gro...

A synergistic effect is noted when Flupirtin is combined with an anticholinergic spasmolytic.

The present invention is concerned with the therapeutic composition comprising as an active ingredient a compound of the formula: and salts thereof; wherein Ar and Ar.sub.1 are independently phenyl, naphthyl or a nitrogen, oxygen, or sulfur heterocyclic ring; Z is an alkylene chain containing from 1 to 5 carbon atoms in the principal chain and up to a total of 10 carbon atoms; M is oxygen, sulfur, or NR.sub.5 ; R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each independently H, lower alkyl, lower al...

A method for the treatment of cerebrovascular contraction in mammals involving administration of a pharmaceutical composition containing as an effective ingredient a p-guanidinobenzoic acid derivative represented by the formula ##STR1## wherein R denotes a group represented by the formula ##STR2## or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.