The present invention relates, in general, to the treatment of estrogen-dependent diseases and disorders and, in particular, to a method of treating estrogen-dependent cancers, particularly breast cancer, with antiestrogens.

Methods and devices for maintaining a desired therapeutic drug effect over a prolonged therapy period are provided. In particular, oral dosage forms that release drug within the gastrointestinal tract at an ascending release rate over an extended time period are provided. The dosage forms may additionally comprise an immediate-release dose of drug.

Methods and devices for maintaining a desired therapeutic drug effect over a prolonged therapy period are provided. In particular, oral dosage forms that release drug within the gastrointestinal tract at an ascending release rate over an extended time period are provided. The dosage forms may additionally comprise an immediate-release dose of drug.

A process for treating adult respiratory distress syndrome by the systemic administration of ibuprofen (p-isobutylhydratropic acid) or a salt or ester thereof. Dosage forms are also disclosed.

Pharmaceutical compositions acting on the metabolism which contain as active derivatives of the 4-hydroxy-3,5-di-akylphenyl-propionic acid corresponding to the formula I and II ##EQU1## wherein R.sub.1 and R.sub.2 which may be identical or different, each stands for an alkylradical having 1 to 8 carbon atoms, R.sub.3 stands for an alkylene radical having 2 to 12 carbon atoms, X stands for hydroxy, alkoxy having 1 to 18 carbon atoms, phenalkoxy having 1 to 4 alkyl carbon atoms, cycloalkoxy having...

A process for treating adult respiratory distress syndrome by the systemic administration of flurbiprofen (3-fluoro-4-phenylhydratropic acid) or a salt or ester thereof. Dosage forms are also disclosed.

A process for treating the blood-brain barrier by the systemic administration of flurbiprofen (3-fluoro-4-phenylhydratropic acid) or a salt or ester thereof. Dosage forms are also disclosed.

A process for treating the blood-brain barrier by the systemic administration of ibuprofen (p-isobutylhydratropic acid) or a salt or ester thereof. Dosage forms are also disclosed.

A process for treating Herpes Type II virus by the systemic administration or topical application of ibuprofen (p-isobutylhydratropic acid) or a salt or ester thereof. Dosage forms are also disclosed.

A nonsteroidal anti-inflammatory drug which is phenylacetic acid derivative and methods of using the same in topically controlling eye inflammations.