P-CHLOROPHENYLALANINE AND ITS PHARMACEUTICALLY-ACCEPTABLE ACID ADDITION SALTS ARE USEFUL IN RELIEVING THE SYMPTOMS OF THE CARCINOID TUMOR SYNDROME.

(+)-.beta.-Amino-.beta.-(3,4-dimethoxy-phenyl)-propionic acid and its salts are useful as anti-hypertensive agents.

The antidepressant action of tricyclic antidepressants is enhanced by concurrent administration of thyroid hormone. A composition for treating depression comprises a tricyclic antidepressant and a thyroid hormone in pharmaceutically effective amounts admixed with a pharmaceutical carrier. 8 Claims, No Drawings

3-(2,5-Dihydroxyphenyl)-alanine, in its racemic form as well as the individual optical isomers thereof possess significant activity as cardiac stimulants. Various derivatives of the racemic mixture are prepared which are resolved into the component optical isomers. The racemic mixture and the enantiomers are employed in compositions which are administered as cardiac stimulants.

Compounds are disclosed having the structure of Formula I: ##STR00001## where R.sup.1 , R.sup.3, and R.sup.4 are independently hydrogen or C.sub.1 to C.sub.4 alkyl, and R.sup.2 is: ##STR00002## where R.sup.5 is selected from the group consisting of hydrogen and C.sub.1 to C.sub.4 alkyl, or ##STR00003## where R.sup.6, R.sup.7 and R.sup.8 are independently hydrogen or C.sub.1 to C.sub.4 alkyl; or the esters or pharmacologically acceptable salts thereof. Such compounds may be utilized for the proph...

The invention relates to a pharmaceutical preparation comprising levothyroxine sodium, gelatin and fillers, which is free of organic solvent residues.

A method of pharmacologically alleviating craving for and withdrawal from narcotics and amphetamines in human beings which method comprises administering to a human being a therapeutically effective amount of alpha-methyl-para-tyrosine and an alkalinizing agent, with the alkalinizing agent being present in an amount sufficient to cause the urine of the human being to have an alkaline pH. Pharmaceutical compositions adapted for use in the foregoing method are also provided.

A method for treating schizophrenia and a method and composition for potentiating the beneficial effects and reducing the side effects of neuroleptic drugs. Schizophrenia is treated with a GABA-like compound such as Lioresal. Neuroleptic drugs are potentiated by coadministering to a schizophrenic a neuroleptic drug and a GABA-like drug such as Lioresal.

Disclosed are a clear aqueous solution of diclofenac sodium dissolved in a mixed solvent of a fatty acid dialkylolamide and water; an anti-inflammatory analgesic composition excellent in percutaneous absorption, which comprises the clear aqueous solution and a higher unsaturated aliphatic alcohol contained in the solution; and a self-adhesive cataplasm comprising a cataplasm base and the clear aqueous solution, polybutene and gelatin added in the base. The clear aqueous solution of diclofenac so...

The present invention describes impaired glutamate uptake in glioma cells, and further shows that instead of removing glutamate from the extracellular fluid, glioma cells release large amounts of glutamate. The high levels of extracellular glutamate result in elevated [Ca.sup.2+ ].sub.i followed by widespread neuronal death, which could be prevented by treating neurons with the NMDA receptor antagonists, MK-801 or D-AP5, or by depletion of glutamate from the medium. Significantly, several phenyl...