The present invention provides methods of inhibiting metastasis of a tumor and methods of treating a tumor using a combination of an inhibitor of the activation of nuclear factor NF-.kappa.B and a cancer chemotherapeutic agent. In one embodiment of the present invention, combination of curcumin and paclitaxel (taxol) can be used to treat and inhibit metastasis of breast tumor.

2',3,4,4'-tetrahydroxychalcone and pharmacologically acceptable salts thereof are used as a therapeutic agent for treatment of renal disorders, and have activity for treatment of renal disorders and also for treatment of renal disorders accompanied by digestive disorders, and/or general inflammations, and/or allergic diseases.

Aromatic compounds, or prodrugs thereof, which contain an alkylating site and which are capable of alkylating the thiol group in N-acetyl-L-cysteine, in particular bis-aromatic .alpha.,.beta.-unsaturated ketones, are used for the preparation of pharmaceutical compositions or medicated feed, food or drinking water for the treatment or prophylaxis of diseases caused by microorganisms or parasites, in particular protozoa such as Leishmannia, Trypanosoma, Toxoplasma, Plasmodium, Pneumocystis, Babesi...

The present invention provides a method of inhibiting the activation of the NF.kappa.B transcription factor in an animal in need of such treatment comprising the step of administering to said animal a pharmacologically effective dose of curcumin. Also provided is a method of inhibiting the nuclear translocation of the p65 subunit of the NF.kappa.B transcription factor in a cell or in an animal in need of such treatment comprising the step of administering to said animal a pharmacologically effec...

A non-steroidal anti-inflammatory composition comprising a therapeutically effective amount of active anti-inflammatory agent selected from the group consisting of 1-phenyl-1 cyclohexene, 4-phenylcyclohexanone, and mixtures thereof. The active agent may be formulated in a pharmaceutically acceptable carrier. These compositions are useful in the treatment in mammals of inflammation and other related symptoms, including pain.

A non-steroidal anti-inflammatory composition comprising a therapeutically effective amount of active anti-inflammatory agent selected from the group consisting of 1-phenyl-1 cyclohexene, 4-phenylcyclohexanone, and mixtures thereof. The active agent may be formulated in a pharmaceutically acceptable carrier. These compositions are useful in the treatment in mammals of inflammation and other related symptoms, including pain.

All multiple myeloma cell lines examined showed constitutively active I.kappa.B kinase (IKK), I.kappa.B.alpha. phosphorylation and constitutively active NF-.kappa.B. Curcumin, a chemopreventive agent, suppressed constitutive I.kappa.B.alpha. phosphorylation through inhibition of IKK activity and downregulated NF-.kappa.B. Curcumin also downregulated expression of NF-.kappa.B-regulated gene products such as I.kappa.B.alpha., Bcl-2, Bcl-x.sub.L, cyclin D1 and interleukin-6. Consequently, curcumin ...

Aryl substituted diketones and keto-esters, useful as antiviral agents and insecticides, are prepared by reacting an arylalkyl or arylalkenyl iodide with a metal salt of the appropriate diketone or keto-ester.

The present invention provides an antiallergic agent comprising, as an active ingredient, at least one of a tomato extract, tomato pericarp, naringenin chalcone or its derivatives, tricaffeoylquinic acid or its derivatives and dicaffeoylsuccinylquinic acid or its derivatives; a histamine-release inhibitor or a leukotriene-release inhibitor; and a medicament, food, drink or cosmetic comprising the antiallergic agent, the histamine-release inhibitor or the leukotriene-release inhibitor mentioned a...

An improved potassium chloride emulsion having an acceptable taste is disclosed. The disclosed emulsion is a water-in-oil emulsion comprising, per liter, 500 to 700 ml. water, 8 percent to 24 percent weight to volume sorbitol, 100 to 300 ml. of an edible, non-polar oil, 5 percent to 15 percent by weight potassium chloride, 1 percent to 5 percent weight to volume purified bentonite, 10 to 30 ml. of one or a mixture of edible liquid, non-polar esters of unsaturated fatty acids, 0.01 percent to 1.0...