A process for preparing substituted 5-amino-pyrazolo[4,3-e]-1,2,4-triazolo-[1,5-c]pyrimidine compounds having an aminoalkyl substituent at the 7-position is disclosed, wherein the pyrimidine ring is cyclized using a cyanating agent.

Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S.

The equimolecular salt of piperazine and 1,2-diphenyl-4-butyl-3,5-dioxopyrazolidine is prepared by stirring together separately prepared solutions of the two compounds in the same organic solvent, selected among the ketones, ethers, toluene and chlorinated aliphatic hydrocarbons containing 1 to 3 carbon atoms and by seeding the reaction mixture by means of crystals of the equimolecular salt when temperature of the reaction mixture has decreased to a value at which the seeding crystals are not di...

There are provided certain novel 1,2-dimethyl pyrazolium compounds having nitrogen containing substituents in the 3 or 5 position, and to both a method for controlling plant pathogenic fungi with said compounds and a method for protecting plants from an attack by fungi by applying to the foliage of plants a fungicidally effective amount of said compound.

N-acyl-pyrazoles of the formula ##SPC1## Wherein A is alkylene of one to four carbon atoms; Ar is phenyl, unsubstituted or substituted by one or more of alkyl and alkoxy of one to four carbon atoms, trifluoromethyl and halogen, and Q is ##SPC2## R being saturated or unsaturated alkyl or aralkyl of up to 10 carbon atoms, aryl of up to 10 carbon atoms, unsubstituted or substituted by one or more of alkyl, of 1-4 carbon atoms, amino and methoxy, --NH.sub.2, --N(CH.sub.3).sub.2 or alkoxy of 1-4 carb...

A process for the preparation of a compound of formula (I): ##STR1## which comprises cyclization of a compound of formula (II): ##STR2##

A process for the preparation of a compound of formula (I): ##STR1## which comprises cyclization of a compound of formula (II): ##STR2##

Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S.

The present invention relates to dihydropyrazole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.

This invention relates to compounds of the formula wherein X, Y, Z, m, n and p are as defined within, pharmaceutical compositions containing these compounds and to their use as antipsychotic agents, particularly in the treatment of schizophrenia. Depot derivatives of the compounds are useful for providing long acting effects of the compounds.