Dibenzosuberanyl piperazine derivatives represented by the following formula (I): ##STR1## wherein R represents an aliphatic hydrocarbon group, which may contain one or more heteroatom-containing substituent groups and may preferably contain 2 to 30 carbon atoms, and physiologically acceptable salts thereof; and medicinal compositions containing these dibenzosuberanyl piperazine derivatives and/or physiologically acceptable salts thereof. These compounds show effectiveness in allowing resistance...

2,3,3a,12b-Tetrahydro-8H-dibenzo[3,4;6,7]cyclohept[1,2-d]oxaoles and dibenzo[a,d]cyclohept[1,4]dienes bearing, for example, substituents at the 10- and 11-positions, are prepared, inter alia, from the corresponding dibenzocycloheptatrienones. The products are useful as antidepressants.

Compounds of the class of 1-[2- and 3-[4-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-10-yl)-1-piperazinyl]-alkyl ]-3-alkyl-2-imidazolidinone which can be substituted in 8-position by chloro, methyl or methoxy, and the pharmaceutically acceptable acid addition salts thereof, have a depressant effect on the central nervous system; pharmaceutical compositions comprising these compounds and a method of producing a depressant effect on the central nervous system of warm-blooded animals, are provided; a...

This invention provides a process to prepare (2R)-anti-5-{3-[4-(10,11-difluoromethanodibenzosuber-5-yl)piperazin-1-yl]- 2-hydroxypropoxy}quinoline.

This invention provides a process to prepare (2R)-anti-5-{3-[4-(10,11-difluoromethanodibenzosuber-5-yl)piperazin-1-yl]- 2-hydroxypropoxy}quinoline.

A wiper assembly for cleaning a spiral twist bit on an earth-drilling rig is disclosed. The wiper assembly comprises a first cylindrical tube member mounted on the drilling table of a drill rig. The first tube is mounted concentrically with the drill. A second cylindrical member is mounted concentrically with the first tube and carries, on diametrically opposite portions, pivotally mounted wiper blades. In a first position of the wiper blades, they engage the outer wall of the first tube and are...

Preparation and the anticonvulsant utility of 1-(10-cyano/halo-5H-dibenzo[a,d]cyclohepten-5-yl)-4-[(pyridylmethylene)ami no]piperazines are disclosed.

Drug and multidrug resistant modulators of the formula: ##STR1## where R.sup.1 and R.sup.2 are independently hydrogen or halo; A is --CH.sub.2 --CH.sub.2 --, --CH.sub.2 --CHR.sup.4 --CH.sub.2 --, or --CH.sub.2 --CHR.sup.5 --CHR.sup.6 --CH.sub.2 --, where R.sup.4 is --H, --OH, or acyloxy; one of R.sup.5 or R.sup.6 is --H, --OH, or acyloxy, and the other is --H; R.sup.3 is a polyaryl; and pharmaceutically acceptable salts and solvates thereof, are described and claimed. Use of the new compounds in...

Drug and multidrug resistant modulators of Formula (C): ##STR1## where Z is selected from the group consisting of --S--, --S(O).sub.w --, and --CH.sub.2 --, where w is 1 or 2; and pharmaceutically acceptable salts or solvates thereof are described and claimed. Use of the new compounds in the preparation of pharmaceutical compositions is described and claimed. In addition, methods for treating drug and multidrug resistance in various diseases using a compound of this invention are described and c...

This invention provides a process to prepare 10,11-(optionally substituted)methanodibenzosuberane derivatives. The invention also provides an intermediate in this process.