Spiromonomers with enhanced reactivity and ring-opening proficiency of the formulae: ##STR1## wherein R.sub.1 represents a C.sub.1 -C.sub.6 alkenyl, R.sub.2 represents hydrogen or C.sub.1 -C.sub.6 alkenyl, R.sub.3 represents a C.sub.1 -C.sub.6 alkyl or C.sub.3 -C.sub.8 cycloaliphatic unsubstituted, or substituted with halo, C.sub.1 -C.sub.6 alkyl, alkoxy, hydroxy, or one of one or more hetero atoms; and R.sub.4 represents a C.sub.1 -C.sub.6 alkyl or C.sub.3 -C.sub.8 cycloaliphatic unsubstituted,...

A process for the preparation of 1,2-O-(1-methylethylidine)-.alpha.-L-sorbofuranose and 6-(n-substituted amino)-6-deoxy-1,2-O-(1-methylethylidine)-.alpha.-L-sorbofuranose and derivatives of the formula: ##STR1## wherein R' is benzyl or R, wherein R is hydrogen, alkyl of 1 to 13 carbon atoms, and aralkyl wherein alkyl is a lower alkyl of 2 to 6 carbon atoms and aryl is phenyl, unsubstituted or substituted with lower alkyl of 1 to 6 carbon atoms, halo, lower alkoxy of 1 to 4 carbon atoms or thio l...

A method for producing spiro-orthocarbonate compounds is disclosed. The method comprises reacting a cyclic carbonate compound of the following formula with an epoxy compound containing an epoxy group: ##STR1## wherein R is an alkylene group or a substituted alkylene group. The disclosed method makes it easy to commercially produce spiro-orthocarbonate compounds in a one stage reaction. The starting materials can be easily handled without any hygienic difficulties and the method can be carried ou...

Novel strobilurine derivatives which are suitable for the treatment of disorders and as fungicides are described.

Safe, effective first-pass inhibiting compounds and citrus-derived substances are provided. Formulations containing the compounds are also provided as are methods for inhibiting the first pass effect.

15-Oxasteroids of the androstane, pregnane, estrane, and 19-norpregnane series are useful as hormonal agents.

A compound of the formula ##SPC1## Wherein R is an alkyl having 1 to 4 carbon atoms, is prepared by condensing, in a benzene medium, the corresponding 4'-bromomethyl derivative, with R--NH.sub.2. The compounds possess analgesic, anti-inflammatory, tranquilizing, hypotensive, vasodilatatory, anti-arythmic, diuretic, spasmolytic, anti-cholinergic, anti-histaminic, anti-ulcerous and anti-serotonine properties.

A process for producing spiro-orthocarbonate having glycol unit (2) is described, which comprises reacting a spiro-orthocarbonate having glycol unit (1) which is different from glycol unit (2), with a glycol having glycol unit (2) to release a glycol having glycol unit (1).

In the preparation of (poly)cyclic polyethers by a cyclic Williamson synthesis, the improvement of contacting the reactants in a hindered (C.sub.4 -C.sub.14) alkanol. For example, bis-chloroethyl ether and the disodium salt of tetraethylene glycol are contacted in t-butanol to produce the cyclic polyether ##STR1## in high yields.

15-Oxasteroids of the androstane, pregnane, estrane, and 19-norpregnane series are useful as hormonal agents.