The object of the present invention is a novel mandelate salt of a substituted tetracyclic tetrahydrofuran derivative according to Formula (I) ##STR00001## the N-oxide forms and the stereochemically isomeric forms thereof, wherein R.sup.1 and R.sup.2 each independently are hydrogen or C.sub.1-6alkyl and R.sup.3 and R.sup.4 each independently are hydrogen or halogen. In the foregoing definitions C.sub.1-6alkyl defines straight and branched saturated hydrocarbon radicals having from 1 to 6 carbon ...

The present invention concerns processes for the preparation of each of the 4 diastereomers of formula (I) ##STR00001## in stereochemically pure form from either of two enantiomerically pure precursors. The tetracyclic ringsystem having trans-fused five and seven membered rings is formed in an acid-catalysed cyclization reaction. The invention further relates to the thus obtained cis-fused tetracyclic alcohol intermediates, the methanamine end-products, the methanamine end-products for use as a ...

Methods are disclosed for the large-scale isolation of 98.5% pure Nimbin from Neem seeds. The ultimate product is obtained first from an alcoholic extraction with subsequent partitioning using chlorinated hydrocarbon solvents. A resulting partitioned layer, which is recovered and concentrated, is then stripped with a hydrocarbon solvent, distilled and cooled to ambient temperature. The resulting mass is mixed and washed in a second hydrocarbon solvent, after which the resulting solid is washed i...

15-Oxasteroids of the androstane, pregnane, estrane, and 19-norpregnane series are useful as hormonal agents.

A benzofuran compound of the formula ##STR1## wherein A represents ##STR2## wherein R.sub.1, R.sub.2, R.sub.3, B and D have various meanings. The benzofuran compound is usefully employed in pharmaceutical and cosmetic compositions.

15-Oxasteroids of the androstane, pregnane, estrane, and 19-norpregnane series are useful as hormonal agents.

15-Oxasteroids of the androstane, pregnane, estrane, and 19-norpregnane series are useful as hormonal agents.

Novel benzopyran analogs are disclosed. Also disclosed are methods for the lowering and controlling of normal or elevated intraocular pressure as well as a method for the treatment of glaucoma using compositions containing one or more of the compounds of the present invention.

A stable liquid composition comprising warfarin sodium, glycerin, an alcohol such as ethanol, and a pH buffer such as a phosphate buffer providing a pH above 7 is provided. The stability of the composition is characterized by the amount of warfarin sodium in the composition degraded after 1 month at room temperature, which is 5% or less. A method for preparing the composition and a method for providing an anti-coagulant therapy are also disclosed.

The present invention concerns a process for preparing each of the 4 individual diastereomers of formula (I) in stereochemically pure form from a single enantiomerically pure precursor. The tetracyclic ringsystem having cis-fused five and seven membered rings is formed in a base-catalysed cyclization reaction. The invention further relates to the thus obtained cis-fused tetracyclic alcohol intermediates and methanamine end-products, and the methanamine end-products for use as a medicine, in part...