The present invention relates to novel, non-secosteroidal, phenyl-benzofuran compounds with vitamin D receptor (VDR) modulating activity that are less hypercalcemic than 1.alpha.,25 dihydroxy vitamin D3. These compounds are useful for treating bone disease and psoriasis.

The invention relates to novel heterocycles of formula (I), processes for their preparation and their use for preparing medicaments for the treatment or prophylaxis of disorders, especially of hyperproliferative disorders. ##STR00001##

The hydrolysis of 2,3-dihydro-2,2-dimethylbenzofuran-7-diazonium bisulfate to produce 2,3-dihyro-2,2-dimethyl-7-benzofuranol is carried out in the presence of a catalytic amount of a cuprous compound. The cuprous compound accelerates hydrolysis of the diazonium salt with concomitant reduction of tarry by-products.

An industrially useful process for producing benzofuran derivatives of formula (1): ##STR1## by formylating a compound of formula (2): ##STR2## (where A.sub.1 is a protective group), followed by reaction with a compound of formula (4): ##STR3## (where X.sub.1 is a halogen atom), then performing a cyclizing reaction and subsequently performing a reaction for hydroxyl group deprotection.

A substituted carboxylic acid derivative which is fungicidally active is provided. The compound has the formula: ##STR1## wherein R.sub.1 stands for a methyl or ethyl group, A stands for ##STR2## R.sub.2 stands for a methyl, ethyl or trifluoromethyl group, R.sub.3 stands for a methyl group or a halogen or hydrogen atom, R.sub.4 stands for a fluorine or hydrogen atom, R.sub.5 stands for a methyl, nitro or trifluoromethyl group or a halogen atom, Z stands for a .dbd.CH-- group or an N atom, R.sub....

The present invention relates to the process for the preparation and purification of citalopram (I) ##STR1## in which a compound of formula (II) ##STR2## wherein Z is iodo, bromo, chloro or CF.sub.3 --(CF.sub.2).sub.n --SO.sub.2 --O--, n being 0, 1, 2, 3, 4, 5, 6, 7 or 8, is subjected to a cyanide exchange reaction with a cyanide source; the resultant crude citalopram product is optionally subjected to some initial purification and subsequently treated with an amide or an amide-like group formin...

To provide highly safe therapeutic or preventive agents for hyperuricemia, more specifically uricosuric agents, which have potent uricosuric effect and do not cause grave hepatic disorder. Medicinal compositions for the treatment or prevention of hyperuricemia or diseases caused by hyperuricemia, which contain 6-hydroxybenzbromarone or salts thereof, and pharmaceutically acceptable carriers; uricosuric agents, xanthine oxidase inhibitors, and inhibitors against the uptake of uric acid in kidney,...

Various divalent ligands based on khellinone derivatives are described. These derivatives can be useful in the modulation of potassium channel activity in cells, including among others Kv1.3 channels found in T-cells. The compounds may also be useful in the treatment or prevention of autoimmune and inflammatory diseases, including multiple sclerosis.

A novel aminocoumaran derivative of the general formula (I): ##STR1## wherein R.sup.1 and R.sup.2 are a hydrogen atom, an acyl group, an alkoxycarbonyl group, an aliphatic group or aromatic group; R.sup.3, R.sup.4 and R.sup.5 are an optionally acylated hydroxyl optionally substituted amino group, alkoxy group or aliphatic group, or two of R.sup.3, R.sup.4 and R.sup.5 may be linked together to form a carbocyclic group; R.sup.6 and R.sup.7 are an aliphatic group and at least one of them has a meth...

Alkyl ethers of 2,3-dihydrobenzofuran where the alkyl chain may contain branched chains, unsaturated bonds, epoxy bridges, and may be substituted with halo, alkoxy, lower alkenyloxy, or lower alkynyloxy substituents useful in killing and preventing the proliferation of insects and other pests by upsetting their hormone balance.