The present invention relates to the preparation of 3-methylamino-1-(2-thienyl)-1-propanone and its use for preparing the pharmaceutical (+)-(S)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine oxalate--(trade name Duloxetine.RTM.).

A process for the preparation of [2-(2-thienyl)-ethylamino]-(2-halogenophenyl)-acetonitriles of general formula (I) starting from 2-(2-thienyl)-ethyl-amine, alkalicyanide and o-halogeno-benzaldehyde. Compounds of general formula (I) are valuable intermediates.

Compounds are prepared having the formula ##SPC1## Wherein the thienyl group can be substituted with one or more lower alkyl groups; the bridging member either has the structure or the structure and R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are hydrogen or lower alkyl groups, R.sub.5 is hydrogen or hydroxy, R.sub.6 and R.sub.7 are the same or different and are hydrogen, halogen, hydroxy, lower alkyl, halo lower alkyl, or lower alkoxy and the groups R.sub.8 and R.sub.9 are the same or different and a...

This invention relates to aminoethylthiophene derivatives and more particularly 2- and 3-aminoethylthiophene derivatives which are useful as antiarrhythmic agents, their methods of use as antiarrhythmic agents, and novel intermediate compounds useful for preparation of the aminoethylthiophene derivatives of the invention.

In the process according to the invention 2-thiophene acetonitrile is reacted with 2-chlorobenzylamine and hydrogen in the presence of a hydrogenation catalyst. The product obtained is a chemical intermediate useful in the pharmaceutical industry.

5-(4-Aminophenyl)-2-thiophenecarboximidamide hydrochloride hemihydrate is useful as an antidepressant agent.

The invention has as its subject a process for the preparation of thienylethylamines of the formula where R represents the group ##STR1## and R' represents hydrogen or a group identical to R, by catalytic hydrogenation of a compound of the formula ##STR2## synthesis intermediates.

Nonlinear optically active compounds, macrostructures that include nonlinear optically active components, and devices including the macrostructures. The nonlinear optically active compounds include dendrimers having two or more nonlinear optically active components. In certain embodiments, the compounds and dendrimers are crosslinkable.

A stream guide finger is mounted coaxially within a spinneret capillary and extends downwardly beyond the capillary discharge opening, reducing the tendency of the molten stream to flick, bend or drip.

Thiophene compounds of formula: ##STR1## wherein R.sub.1 represents an alkyl radical containing 1 to 4 carbon atoms, a cycloalkyl, cycloalkenyl or aralkyl radical, R.sub.2 represents an atom of hydrogen or a methyl radical with the proviso that when R.sub.2 represents methyl R.sub.1 represents alkyl, or R.sub.1 and R.sub.2, when they are taken together, represent, with the carbon atom to which they are attached, a cyclopolymethylene radical having from 3 to 6 carbon atoms, whereby a reaction med...