Synthetic methods for lactone-containing compounds such as the discodermolides are provided, as are compounds which mimic the chemical and/or biological activity thereof, and methods and intermediates useful in their preparation.

A process for the purification of mandelic acid N,N-diethylamide, DEM, by forming a crystalline adduct of DEM with a calcium halide and water.

New 4-acylaminophenylacetamidines of the formula: ##SPC1## In which R is a straight or branched chain alkoxyalkyl having 3 to 8 carbon atoms or straight or branched chain alkenyloxyalkyl having 3 to 8 carbon atoms wherein the alkoxy moiety or alkenyloxy moiety may substituted by alkoxy or phenyl, and including the non-toxic pharmacologically acceptable salts thereof. The products have utility as parasiticides. The products are obtained by either of two methods: (1) via the reaction of an N'-(4-a...

New anticonvulsant compounds include (.+-.)-2-hydroxy-2-phenylbutyramide and (.+-.)-3-hydroxy-3-phenylpentamide. These homologues of (.+-.)-4-hydroxy-4-phenylhexanamide have anticonvulsant activity as well as unexpected properties, particularly low neurotoxicity and pharmacological differences. The invention further provides methods for the synthesis of (.+-.)-2-hydroxy-2-phenylbutyramide and (.+-.)-3-hydroxy-3-phenylpentamide as exemplified in the examples.

An amide compound given by formula [I]: ##STR1## wherein R.sup.1 represents a C1-C10 haloalkyl and so on, R2 represents a hydrogen and so on, X represents an oxygen or sulfur, Y represents an oxygen or sulfur, Ar represents an aromatic group, A represents an ethylene and so on, and Z.sup.1 and Z.sup.2 represent alkyl, alkoxy and so on, and a fungicide containing it as an active ingredient.

Novel compounds and compositions including those compounds, as well as methods of using and making the compounds are herein described. The compounds are useful in therapeutic applications, including modulation of disease or disease symptoms in a subject (e.g., mammal, human, dog, cat, horse). The compounds are useful as modulators of the mu opioid receptor (MOR) through their binding affinity with that receptor.

The present invention relates to an androgen receptor alkylating compound, wherein the compound may include, inter alia, an active functional group, which permits the alkylation of the androgen receptor.

There is described method and apparatus for taking a biopsy wherein the apparatus is formed of a biocompatible cylindrical member with an outer wall and a hollow core, the cylindrical member having a longitudinal axis. An opening in the outer wall of the member is provided and a cutting device cuts tissue entering the opening as it travels along the opening. Cut tissue is treated with a coagulating agent or member so that the coagulation occurs concurrently or just after the tissue is cut wherei...

The invention relates to .alpha.-oxygenated or .alpha.-thiolated carboxylic acid phenethylamide derivatives of the general formula I including the optical isomers thereof and mixtures of such isomers, wherein A stands for optionally substituted aryl or optionally substituted heteroaryl; X is oxygen or sulfur; Y is oxygen or sulfur; R.sub.1 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, haloalkyl, haloalkenyl, haloalkynyl or halocycloalkyl; R.sub.2 is hydrogen, alkyl, alkenyl, alkynyl, cycloal...

Methods are provided for collecting and processing autologous biological materials to form autologous angiogenic agents. Apparatus and methods also are provided for performing percutaneous myocardial revascularization wherein an injection needle is disposed in spaced-apart relation to the channel-forming tool, so that a predetermined amount of the autologous angiogenic agent may be injected into the myocardium adjacent to the PMR channel.