The present invention relates to N-[(1-dimethylaminocycloalkyl)methyl]benzamide derivatives having the general formula I ##STR00001## wherein n is 0, 1, 2 or 3; R.sub.1 and R.sub.2 are independently H, (C.sub.1-4)alkyl or (C.sub.1-4)alkyloxy; R.sub.3 is (C.sub.3-8)alkyl, (C.sub.4-7)cycloalkyl, (C.sub.4-7)cycloalkyl (C.sub.1-3)alkyl, (C.sub.6-12)aryl(C.sub.1-3)alkyl (wherein the aryl moiety is optionally substituted with 1 3 substituents selected from (C.sub.1-4)alkyl, (C.sub.1-4)alkyloxy, haloge...

Compounds and pharmaceutical compositions containing the same are provided, which are useful in therapeutic treatment or prevention of various diseases.

A radioimmunoassay procedure has been discovered for bupropion [(.+-.)-2-t-butylamino-3-chloropropiophenone], an antidepressant compound, in biological fluids. Novel compounds of formula ##STR1## wherein either R.sub.2 is oxygen and R.sub.1 is (CH.sub.2).sub.n --O--(CO).sub.m --(CH.sub.2).sub.p --COOH where n is an integer from 0 to 5, m is 0 or 1, and p is an integer from 1 to 4; or R.sub.1 is hydrogen and R.sub.2 is N--O--(CH.sub.2).sub.q --COOH where q is an integer from 1 to 3, and novel met...

N-octyl salicylic acid amide and N-decyl salicylic acid amide, a process for their production from salicylic acid methyl ester and a primary amine, and use of the amides in antimicrobial compositions.

The present invention is a process, including intermediates, to produce (2S)-2-dipropylamino)-6-ethoxy-2,3-dihydro-1H-indene-5-carboxamide ##STR1## which is a useful pharmaceutical agent.

Compounds of the formula: ##SPC1## Wherein R.sub.1 and R.sub.2 are each branch-chain alkyl of 3 to 8 carbon atoms and R.sub.3 and R.sub.4 are each hydrogen, alkyl of 1 to 18 carbon atoms, or cycloalkyl of 5 or 6 carbon atoms are useful as light stabilizers in polyolefins. They may be prepared (a) by reacting the 3,5-di-alkyl-4-hydroxybenzoyl chloride with the appropriate amine in the presence of an acid acceptor or (b) by reacting the corresponding benzoic acid with the appropriate amine in the ...

The present invention relates to a process and a catalyst for hydrogenation of aromatic nitro or nitroso (nitrosated) compounds. The process, useful in hydrogenation, especially in the liquid phase, of compounds, nitroaromatic ones in particular, is defined in that the said compound is hydrogenated in the presence of tungsten carbide, the partial pressure of hydrogen being at least equal to two atmospheres (2.times.10.sup.5 pascals). The process also has application to organic synthesis.

A novel antiproliferative drug and methods are disclosed. The drug has the general structural formula: ##STR1## where R1=OR.sub.1 ', SR.sub.1 ', or N(R.sub.1 'R.sub.1 ").sub.2, where R.sub.1 ' and R.sub.1 " are H or lower alkyl groups, and R.sub.2 is an acylamino, or aroylamino group. The compound is useful for inhibiting cell proliferation in drug-resistant tumor cells. Also disclosed is a method of chemical converting a colchicine derivative to form an active inhibitor of DNA topisomerase II.

A method is provided for preparing aromatic acetamides comprising reacting an aryl methyl ketone containing the same number of carbon atoms as the aromatic acetamide, with sulfur and ammonia under substantially anhydrous conditions. The method is particularly useful for the preparation of 4-hydroxyphenylacetamide from 4-hydroxyacetophenone.

The invention provides oil-soluble multivalent metal ion salts of a compound of the formula XNR.sup.1 R.sup.2, in which R.sup.1 and R.sup.2 are the same or different and each are selected from hydrogen and hydrocarbon based radicals having from 1 to 30 carbon atoms, X is an acyl radical of an aromatic ortho-hydroxy carbozxyic acid having a ring substituent which is a hydrocarbon based radical having at least 4 carbon atoms, a process for their preparation, and their use, as additives, in lubrica...