A process for the preparation of polymorph Form I of 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5] benzodiazepine, or olanzapine.

The present invention concerns a novel therapeutic use as a sleep-promoting agent for the known pharmaceutical compound 10-[2-(1-methyl-2-piperidyl)ethyl]-2-methylsulphinylphenothiazine of the formula: ##STR1##

S-triazolo[1,5-d][1,4]benzodiazepin-6(7H)-ones, e.g., 7-methyl-10-chloro-5H-s-triazolo[1,5-d][1,4]benzodiazepin-6(7H)-one are useful as minor tranquilizers, anti-convulsants and sleep-inducers.

This invention concerns the use of the compound 2-nitro-11-(4-methyl-1-piperazinyl)dibenzo[b,f][1,4]-thiazepine, as a neuroleptic agent.

Disclosed are 1-p-(.omega.-aminoalkoxy)phenyl-3,5-diaryl-cycloheptanes useful as hypolipidemic agents, and intermediates useful in the preparation of said compounds including the corresponding cycloheptan-1-ols.

Disclosed are 4-p-(.omega.-aminoalkoxy)phenyl-1,2-diaryl-cyclopentanes useful as hypolipidemic agents, and intermediates useful in the preparation of said compounds including the corresponding 3-cyclopentenes and cyclopentan-4-ols.

This disclosure relates to the aspermatogenesis activity of (a) compounds of the formula: ##STR1## where m is an integer from 1 to 4 X represents hydrogen or --OH R represents Ar, ##STR2## Ar represents ##STR3## R.sub.1 represents hydrogen, fluoro, chloro, lower alkyl or lower alkoxy, R.sub.2 and R.sub.3 each, independently, represent lower alkyl, or R.sub.2 and R.sub.3 together with N represent ##STR4## wherein n is 1, 2 or 3, R.sub.4 represents hydrogen or lower alkyl, and R.sub.5 represents h...

This invention relates to a composition and method for potentiating the antidepressant effect of dibenzocycloheptadiene-type antidepressant agents, for example, nortriptyline, in the treatment of depression, especially geriatric depression, by administering them in combination with an approximately 1:1:1 by weight mixture of dihydroergocryptine (2:1 .alpha.:.beta.), dihydroergocornine and dihydroergocristine.

Dry souffle compositions having malto/Dextrin and Zanthan gum and wherein the resulting soufflees have an improved foam structure.

Compounds of the formula ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are alkyl or aryl groups, A, B, C and D are non-reactive substituents or two are joined to form an additional ring, and Z is either of the formula Z': ##STR2## wherein R.sup.4 is H, lower alkyl or a cation; or a -6-oxotetrahydropyran-2-yl ring of the formula Z": ##STR3## e.g. 4-hydroxy-6-{2-[2-(methyldiphenylsilyl)phenyl]ethenyl]ethyenyl}-tetrahydro -2H-pyran-2-one, (trans, trans). The compounds inhibit cholesterol biosynthes...