The present invention describes an in vivo method, using pulsed electric field to deliver therapeutic agents into cells of the skin and muscle for local and systemic treatments. In particular, therapeutic agents include naked or formulated nucleic acid, polypeptides and chemotherapeutic agents.

In vivo methods are provided for using an electric field to delivery therapeutic treatment to a subject while reducing inducement of histopathological change in the target muscle tissue, such as is associated with induction or amplification of an immune response caused by the pulsed electric field. Therapeutic agents can be delivered nto cells of muscle for local and systemic treatments with optimal gene expression and minimal tissue damage. In particular, therapeutic agents include naked or for...

An electrode assembly for an apparatus for trans-surface molecular includes a non-conductive carrier having a proximal surface, a distal surface, and a plurality of through holes from the proximal surface to the distal surface, a plurality of first electrodes disposed on the proximal surface, a first conductor disposed on at least a first portion of the distal surface and extending through at least a first portion of the plurality of through holes and connected to the first electrodes on the pro...

A method for in vivo electrotherapy, or electroporation-mediated therapy, using a needle array apparatus is provided. Treatment of tumors with a combination of electroporation using the apparatus of the invention, and a chemotherapeutic agent, caused regression of tumors in vivo.

The present invention concerns an improved optical method and optical sensing device for determining the levels of polyhydroxyl-substituted organic molecules in vitro and/or in vivo in aqueous media. The range of detection is between about 400 and 800 nm. In particular, a sensory devise is implemented in a mammal to determine sugar levels. Specifically, a dye is combined with a conjugated nitrogen-containing heterocyclic aromatic boronic acid-substituted bis-onium compound in the presence of a s...

Devices for locating misplaced keys are described. Such devices include a housing in which is disposed a cell phone receiver, a ringer, associated circuitry, a power supply, and an "on/off" switch". Such devices may also include a battery life indicator disposed in the housing, which indicator is visible to a user.

Embodiments include a collapsible utility pole that snowboarders can carry easily in their pants pocket and can be quickly pulled out and extended to a completely rigid pole to push themselves over flat sections of downhill runs. The utility pole can also being useful when getting off the chair lift to move toward the slopes. Embodiments of the device have the capability of being converted into a small shovel or ice pick by detaching the snow basket and attaching a desired device.

Sport ball training devices and methods for releasably holding a tennis ball or other sport ball at an appropriate height for the practice of striking the ball, either directly or indirectly with a racket or the like. An embodiment may have a support device with a base and an adjustable vertical tubular assembly for the support of a transverse arm from which a ball sling is suspended. A retainer member of the ball sling circumferentially holds a sport ball. An embodiment of the retainer member m...

Interleukin-5 receptor (IL-5R) ligands comprising amino sequences of formula TGGGDGYVX.sub.3VE X.sub.4 ARCPTCK, EGYVX.sub.3VE X.sub.4 ARCPTCK, EGYVX.sub.3VE X.sub.4 ARCPTCR, GYVX.sub.3VE X.sub.4 ARCPTCG, EGYVX.sub.3VE X.sub.4 ARCPTCG, GYVX.sub.3VE X.sub.4 ARCPTCR, and EGYVX.sub.3VE X.sub.4 AACPTCR, and methods of using the same, are described and claimed.

A fixed parallel plate micro-mechanical systems (MEMS) based sensor is fabricated to allow a dissolved dielectric to flow through a porous top plate, coming to rest on a bottom plate. A post-deposition bake ensures further purity and uniformity of the dielectric layer. In one embodiment, the dielectric is a polymer. In one embodiment, a support layer is deposited onto the top plate for strengthening the sensor. In another embodiment, the bottom plate is dual-layered for a narrowed gap. Integrate...