Taxanes having an ester substituent at C(10), a hydroxy substituent at C(7), and a range of C(2), C(9), C(14), and side chain substituents.

The present invention relates to a process for the production of vitamin C from L sorbosone using an aldehyde dehydrogenase which is isolated from Gluconobacter oxydans DSM 4025 (FERM BP-3812), said enzyme having the following physicochemical properties: (a) molecular weight of 150,000.+-.6,000 Da or 230,000.+-.9,000 Da (consisting of 2 or 3 homologous subunits, each subunit having a molecular weight of 75,000.+-.3,000 Da); (b) substrate specificity as active on aldehyde compounds; (c) Cofactors...

A system for providing paper models over a wide area computer network includes a user computer that communicates with a model server via the Internet. The model server includes a database of paper model files, e.g., the pieces of the models and assembly instructions. The corresponding method allows a user to access the model server via the Internet and download paper models. The paper models are printed at a printer connected to the user computer. A user can then assemble the paper models follow...

The present invention is directed to a process for the preparation of .beta.-lactams. Generally, an imine is cyclocondensed with a ketene acetal or enolate to form the .beta.-lactam product in a "one pot" synthesis, this process is generally performed at a higher temperature than conventional processes.

The present invention relates to methods of diagnosing spondylocostal dysostosis (SCD) disorders, such as Jarcho-Levin syndrome, in humans for use in genetic counseling and linkage analyses. Methods and compositions for measuring the presence or absence of a specific mutation to Mesp2 associated with Jarcho-Levin syndrome, alone or in combination with other mutations associated with spondylocostal dysostosis, are provided.

The invention provides a system for providing power assisted starting for a variety of gasoline engine devices. In one embodiment, a device comprises a drill having a chuck, a hex shank socket extension coupled to the chuck and a tube. The tube has two dowel pins and the tube is coupled to the drill such that the tube encircles the hex shank socket extension. The tube is configured to couple to an anchor device configured around the hex nut of a bolt securing a flywheel of a gasoline engine.

A method of making a semiconductor device includes the steps of: providing a semiconductor substrate (110, 510, 1010, 1610) having a patterned interconnect layer (120, 520, 1020, 1620) formed thereon; depositing a first dielectric material (130, 530, 1030, 1630) over the interconnect layer; depositing a first electrode material (140, 540, 1040, 1640) over the first dielectric material; depositing a second dielectric material (150, 550, 1050, 1650) over the first electrode material; depositing a ...

The present invention provides processes for the production of docetaxel. Docetaxel is produced by protecting the C(7) and the C(10) hydroxy groups of 10-DAB with a bridging silicon-based protecting group. The resulting 7,10-protected 10-DAB derivative is then derivatized and deprotected to form docetaxel.

Improvements to wind farms and wind generators for harnessing wind energy or generating electricity from wind. Secondary wind turbines are provided at particular locations within a wind farm to generate additional electricity, in some embodiments, using a common electrical power collection system. Enclosures or venturis may surround wind turbines to facilitate mounting close to the ground. Venturis may accelerate wind speed through the turbine and may have a particular shape, may be made of part...

The present invention is a device for atomizing liquids which has: a) a rotatable apparatus for the reception of liquids to be atomized, the apparatus is defined by a cylinder having an interior chamber that runs the length of the cylinder with an internal diameter of about 10 to about 25 millimeters, the cylinder has an upper end with an opening into the interior chamber, which opening is adapted to receive liquids to be atomized, the cylinder has a closed lower end that terminates with a floor...