The present invention relates to spiroisoindolines that are antagonists at the phencyclidine receptor of the N-methyl-D-aspartate receptor complex and which are useful when such antagonism is desired such as in the treatment of neurological disorders. The invention further provides processes for preparing the spiroisoindolines, intermediates useful for their synthesis, pharmaceutical compositions containing them, and methods for their use.

A polyisocyanate composition, suitable for use in the production of elastomers by the RIM process, said composition being the product of reacting an alcohol and/or thiol having an average hydroxyl and/or thiol functionality of from about 1.5 to about 4 and an average hydroxyl and/or thiol equivalent weight of at least 500 with at least 2 equivalents, per hydroxyl and/or thiol equivalent, of an organic polyisocyanate under such conditions that at least about 20% of the initially formed urethane a...

A dispersion in an aromatic polyisocyanate of a reaction product of the polyisocyanate and an amine having the formula: ##STR1## wherein Q represents hydrogen or hydrocarbyl and R represents a hydrocarbyl radical selected from radicals of the formulae: ##STR2## or wherein R and Q together with the attached nitrogen atom form a piperidine, morpholine or pyrolidine ring bearing a hydrocarbyl radical on at least one of the carbon atoms adjacent to the nitrogen atom.

Polyureas are prepared from a system of (A) a polyisocyanate; and (B) a mixture of polyamines containing (i) from 60 to 25 percent by weight of the mixture of an aromatic polyamine; and (ii) from 40 to 75 percent by weight of the mixture of an aliphatic polyamine.

Modified organic isocyanate composition containing urea and/or biuret groups and/or salts of these groups, obtained from the reaction of a blocked polyamine composition and an unblocked isocyanate composition.

A bowling ball having at least an outer portion fabricated from the reaction of reactants comprising (i) a polyisocyanate, (ii) an active hydrogen-containing compound having an average functionality of at least 2.0, and (iii) a slip agent compound containing a moiety which imparts lubricity to said ball, said slip agent compound also having at least one active hydrogen-containing group which is reactive with isocyanate groups, said slip agent compound being present in an amount between about 0.5...

Polymers having substituted urea groups, and molded objects therefrom, can be made by reacting, in a reaction injection molding (RIM) process, a composition comprising (A) a polyisocyanate and (B) a mixture comprising an imino functional resin and a chain extender. The chain extender may also be imino functional.

A system for use in making molded polyurethane objects by an open or closed casting process, said system comprising (A) an aromatic polyisocyanate; and (B) an active hydrogen-containing composition comprising (i) a polyhydric alcohol having an average molecular weight in the range of about 1000 to about 8000 and an average functionality of about 2 to about 4; (ii) a polyhydric alcohol having 2 to 12 carbon atoms and an average functionality of about 2 to about 3; and (iii) a secondary monoamine ...

A tiltable furnace to supply molten metal to a ladle and the ladle is connected to a computing and automatic control system which continuously senses the rate of change of weight of the ladle as liquid is poured from the ladle into a mold. The control system tilts the furnace and the ladle to regulate the flow of liquid into the mold to hold the casting to a predetermined weight. The rate of change of the weight of liquid times the time of the pour will give the weight poured in that time.

A pest control composition in a solid stick form is provided for topical application around the neck or on the face of domesticated animals such as dogs, cats, cattle, horses and the like to control fleas, lice, ticks, flies, and like pests. Topical application about the neck or face of the animal in an amount ranging from about 0.1 to 0.3 grams, preferably about 0.13 to 0.25 grams, per kilogram of body weight results in the elimination of all fleas at the end of twenty to twenty four hours, a s...