Disclosed are compounds of the class of 1,2,3-benzotriazin-4(3H)-ones which are substituted at the 3- position and which are substituted at at least two of the 6,7 and 8- positions by alkoxy or by an adjacent methylenedioxy, e.g. 6,7-dimethoxy-3-(3-morpholinopropylamino)-1,2,3-benzotriazin-4(3H)-one. The compounds have pharmacological activity in animals, e.g. anti-inflammatory activity. The compounds may be prepared, for example, by alkylation of the corresponding 3-unsubstituted compounds and ...

A process for the resin finishing of cellulosic blend fabrics with improvement of their affinity for anionic optical brighteners by treating the fabrics with a solution of a) an N-methylol or N-alkoxymethyl compound b) an acid curing catalyst c) a copolymer consisting of vinyl pyrrolidone units and at least 5.5 weight percent vinyl alcohol units and curing by dry heat treatment at 120.degree.-180.degree.C.

The compounds are biologically active tricyclic pyrimidines of the class of imidazo[1,2-a]pyrido[2,3-d]pyrimidine-5(10H)-ones, pyrido[2,3-d]pyrimido[1,2-a]pyrimidine-6-ones and [1,3]diazepino[1,2-a]pyrido[2,3-d]pyrimidine-7(12H)-ones, e.g., 10-(4'-fluorobenzyl)-2,3-dihydro imidazo[2,1-a]pyrido[2,3-d]pyrimidine-5(10H)-one, and useful, for example, as broncho-dilator agents. Processes for preparation of said compounds include the reaction of a 3,4-dihydro-1,3-dioxo-1H-pyrido[2,3-d][1,3]oxazine (a ...

The compounds are of the class of bis-(4-trifluoromethylphenoxy) acetic acid compounds, e.g., bis-(4-trifluoromethylphenoxy)acetic acid 1-methyl-4-piperidyl ester. The compounds are useful as hypocholesteremic/hypolipemic agents. 12 Claims, No Drawings

Compounds of the formula ##STR1## in which R.sub.1 is --CH.sub.2 CH.sub.2 OH, --CH.sub.2 CHOHCH.sub.2 OH, --CH.sub.2 COCH.sub.3, --CH.sub.2 COC.sub.6 H.sub.5, --CH.sub.2 COC.sub.6 H.sub.4 Br or --NR.sub.8 R.sub.9, R.sub.2 is halogen or cyano, One of R.sub.3 and R.sub.3 ' is hydrogen and the other is hydrogen or halogen, R.sub.4 is hydrogen, chloro, bromo, methyl, methoxy or ethoxy, R.sub.5 is chloro, bromo, cyano, acylamino, methyl, methoxy or ethoxy, with the proviso that, when R.sub.5 is methy...

Substituted dimethyl aminomethyl benzylidene bicyclic and tricyclic compounds, e.g., 5-(o-dimethylaminomethylbenzylidene)-10,11-dihydro-5H-dibenzo[a,d]cyclohep tene, are prepared by treating a substituted dimethylamino benzyl lithium compound with bicyclic and tricyclic ketones and are useful as major tranquilizers and muscle relaxants.

Substituted or unsubstituted 10,11-dihydro-5H-benzo[4,5]cyclohepta[1,2-b] pyrazines, e.g. 10,11-dihydro-5H-benzo[4,5]cyclohepta[1,2-b] pyrazine, are prepared by treating a 6-hydroxy-7H-benzocyclohepten-7-one with ethylenediamine, and are useful as sedative-hypnotic agents, minor tranquilizers and anti-convulsant agents.

The invention concerns novel compounds of the formula: ##SPC1## Wherein R.sub.1 is hydrogen or alkyl of one to three carbon atoms, and R.sub.2 is hydrogen, fluorine, chlorine, bromine, alkyl of one to three carbon atoms, alkoxy of one to three carbon atoms, or an amido radical in which the alkyl group is of one to three carbon atoms, And pharmaceutically acceptable acid addition salts thereof. The compounds are analgesics.

Organic acid, halogenated organic acid and nitrate esters of N-(N-[cyanoalkyl]-N-nitroso)amino-aminoalcohols, e.g., 4-(N-[1-cyanoethyl]-N-nitroso)amino-1-piperazine-ethanol nitrate, are useful as anti-anginal agents.

Substituted benzyl-10,11-dihydro and corresponding 10,11-unsaturated dibenzocycloheptenols, e.g., 5-(a-amino benzyl)-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ol, useful as diuretics, prepared from a series of reactions starting with a dibenzo-cycloheptenone and lithiated N-benzyl benzamides.