The present invention is directed to compounds of the formula I: ##STR1## (wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.7, R.sup.8, X, n, x and y are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-5 and/or CCR-3.

2,5-Diaryl tetrahydrofurans, 2,5-diaryl tetrahydrothiophenes, 1,3-diaryl cyclopentanes are disclosed that reduce the chemotaxis and respiratory burst leading to the formation of damaging oxygen radicals of polymorphonuclear leukocytes during an inflammatory or immune response. The compounds exhibit this biological activity by acting as PAF receptor antagonists, by inhibiting the enzyme 5-lipoxygenase, or by exhibiting dual activity, i.e., by acting as both a PAF receptor antagonist and inhibitor...

This invention pertains to a process for the preparation of 2,5-dihydrofurans by the isomerization of .gamma.,.delta.-epoxyalkenes in the presence of a catalyst system comprising an organotin compound and an alkali metal iodide.

Disclosed herein are compounds selective for a 5-HT.sub.1D receptor, the compounds having the general formula (I): ##STR1## Also disclosed is the use of these compounds as pharmaceuticals to treat indications where stimulation of a 5-HT.sub.1D receptor is indicated such as migrane.

The present invention is directed to a process for synthesizing 1,5 disubstituted imidazoles with biaryl components of the formula (I): ##STR1## which are usefull as Farnesyl-Protein Transferase inhibitors.

Cosmetic/pharmaceutical/dermatological compositions suited for promoting desquamation of the skin of a mammalian organism in need of such treatment and/or to stimulate epidermal renewal and thus to combat intrinsic and/or extrinsic aging thereof, via topically applying same to the skin of such organism, comprise a cutaneous aging-combating effective amount of at least one polyholoside, preferably a heterogeneous polyholoside, in a topically applicable, cosmetically/pharmaceutically/dermatologica...

The invention provides novel mepiquat plant growth regulator compositions which have improved hygroscopicity and corrosion characteristics. The novel mepiquat plant growth regulator compositions of the invention can be readily prepared from technical mepiquat chlorid inter alia by electrochemical ion exchange processes or by quaternization of N-methylpiperidine with dimethylcarbonate as starting material.

This invention relates to a method of improving the catalytic performance of palladium or ruthenium, rhenium-on-carbon hydrogenation catalysts operating in aqueous media where loss of soluble rhenium may result in rapid catalytic failure. A rhenium-containing hydrogenation catalyst comprised of rhenium on a support material is regenerated by first treating the catalyst with aqueous perrhenic acid or potassium perrhenate followed by treating the catalyst under reducing conditions at elevated temp...

A method for treating diseases which involve interaction of neurokinin B with NK.sub.3 receptors in humans. The method comprises administering a therapeutically effective amount of a NK.sub.3 antagonist compound having the formula: ##STR1## in which: R.sub.1 and R.sub.11 together represent a --(CH.sub.2).sub.3 -group.

Robustaflavone, intermediates and analogues thereof and a method for synthesizing the same are provided. The method involves constructing apigenin ethers containing functionalities at the 6- and 3'-positions which could be cross-coupled using transition metal catalysis. The method also involves development of a regioselective iodination of an apigenin derivative at the 6-position, formation of an apigenin 3'-boronate using a palladium-catalyzed exchange of the corresponding 3'-iodide with a dibo...