A process for the preparation of clopidogrel (1) ##STR00001## by reaction of the N,N'-bis-4,5,6,7-tetrahydro-[3,2-c]-thienopyridyl methane (12) ##STR00002## with (R)-2-chlorophenylacetic acid derivatives of formula (13) ##STR00003## in which X and R have the meanings as indicated in the disclosure.

The present invention relates to synthetic green tea derived polyphenolic compounds, their modes of syntheses, and their use in inhibiting proteasomal activity and in treating cancers. The present invention is also directed to pharmaceutical compositions useful in methods of inhibiting proteasomes and of treating cancers.

A compound of the general formula (I) or (II) wherein X is O, NR.sub.4 or S and R.sub.1-R.sub.8 are as defined in the specification ##STR00001##

The invention relates to a new industrially useable process for preparing tropenol, optionally in the form of the acid addition salts thereof.

Compounds of the formula having anti-tumor activity, wherein R.sub.1 and R.sub.2 are as described herein ##STR00001##

The object of the present invention is a novel mandelate salt of a substituted tetracyclic tetrahydrofuran derivative according to Formula (I) ##STR00001## the N-oxide forms and the stereochemically isomeric forms thereof, wherein R.sup.1 and R.sup.2 each independently are hydrogen or C.sub.1-6alkyl and R.sup.3 and R.sup.4 each independently are hydrogen or halogen. In the foregoing definitions C.sub.1-6alkyl defines straight and branched saturated hydrocarbon radicals having from 1 to 6 carbon ...

The invention relates to pyran derivatives of formula I ##STR00001## and processes and intermediates for their preparation and derivatisation, and the use thereof in liquid-crystalline media.

A compound which is a carbamate of formula: ##STR00001## wherein R1 represents ##STR00002## R2 represents a benzyl, phenethyl, furan-2-ylmethyl, furan-3-ylmethyl, thiophen-2-ylmethyl or thiophen-3-ylmethyl group or a straight or branched alkyl group having 3 to 8 carbon atoms, an alkenyl group having 3 to 8 carbon atoms, or a cycloalkyl group of 3 to 6 carbon atoms; p is 1 or 2 and the substitution in the azoniabicyclic ring may be in the 2, 3 or 4 position including all possible configurations ...

The present invention relates to novel compounds, pharmaceutical compositions and methods for treating tumors, cancer and hyperproliferative diseases including psoriasis, genital warts and hyperproliferative cell growth diseases, including hyperproliferative keratinocyte diseases such as hyperkeratosis, ichthyosis, keratoderma or lichen planus. These compounds are described according to the chemical structure: ##STR00001## where R.sup.1 is H, OH, F, Cl, Br, I, a C.sub.1-C.sub.6 optionally substi...

Process for manufacturing an oxirane by reaction between an olefin and a peroxide compound in a reactor containing a liquid phase, in the presence of water, one or more organic solvents, a catalyst and one or more compounds for increasing the selectivity of the catalyst toward epoxidation reactions, in which: if the process is performed in batchwise mode, the liquid phase present in the reactor when the reaction starts, if the process is performed continuously, all of the liquid phases that are ...