Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered fo...

New pyrimidine or pyridine based compounds, compositions and methods of inhibiting the activity of glycogen synthase kinase (GSK3) in vitro and of treatment of GSK3 mediated disorders in vivo are provided. The methods, compounds and compositions of the invention may be employed alone, or in combination with other pharmacologically active agents in the treatment of disorders mediated by GSK3 activity, such as diabetes, Alzheimer's disease and other neurodegenerative disorders, obesity, atheroscle...

N-substituted derivatives of 5-oximinobarbituric add of the general formula ##STR00001## where X is sulfur; R.sub.1 is selected from the group consisting of saturated or unsaturated alkyl, cycloalkyl, aryl and arylalkyl; and R.sub.2 is selected from the group consisting of hydrogen, saturated or unsaturated alkyl, cycloalkyl, aryl and arylalkyl possessing a biological activity.

The present invention relates to substituted phenylcyclohexanecarboxamides of the formula (I) ##STR00001## to processes for their preparation and to their use in medicaments, in particular for the prevention and/or treatment of cardiovascular disorders.

An object of the present invention is to provide a new .mu.-oxo bridged heterometal compound, which can make the photo-functional materials to have diversified properties, and a production method such that the .mu.-oxo bridged heterometal compound is obtained simply, selectively and with high yield. The present invention provides .mu.-oxo bridged heterometal compounds, NcM1-O-M2Nc, PcM1-O-M2Nc and NcM1-O-M2Pc wherein Nc represents naphthalocyanine, Pc represents phthalocyanine, M1 represents a m...

The invention relates to compounds of the general formula (I): ##STR00001## wherein Ar is optionally substituted aryl or heteroaryl; A is (i) --O--, --S--, --SO.sub.2--, --NH--, (ii) a C.sub.1-4-alkyl- or C.sub.1-6-acyl-substituted nitrogen atom or (iii) a C.sub.1-8-alkylene chain or a heteroalkylene chain having 2 to 8 chain atoms, which optionally contains at least one unsaturation, and which may be substituted and/or contain a bridge to form a saturated or partially or fully unsaturated ring ...

Pharmaceutical compositions and compounds are provided. The compounds of the invention have anti-proliferative activity, and may promote apoptosis in cells lacking normal regulation of cell cycle and death. In one embodiment of the invention, formulations of the compounds in combination with a physiologically acceptable carrier are provided. The pharmaceutical formulations are useful in the treatment of hyperproliferative disorders, which disorders include tumor growth, lymphoproliferative disea...

A compound of the formula (I): ##STR00001## wherein X is hydroxy, protected hydroxy or optionally substituted amino; Y is --COOR.sup.A wherein R.sup.A is hydrogen or ester residue, --CONR.sup.BR.sup.C wherein R.sup.B and R.sup.C each is independently hydrogen or amide residue, optionally substituted aryl or optionally substituted heteroaryl; and A.sup.1 is optionally substituted heteroaryl; provided that a compound wherein Y and/or A.sup.1 is optionally substituted indol-3-yl is excluded, a taut...

This invention describes compounds of Formula (I) which are modulators of potassium channels and are useful for treating conditions affected by abnormal potassium channel activity including erectile dysfunction and irritable bowel syndrome. ##STR00001##

Provided herein is a compound having the formula (I): ##STR00001## Wherein said compounds are useful for the treatment of psychiatric disorders including but not limited to depression, generalized anxiety, eating disorders, dementia, panic disorder, and sleep disorders. The compounds may also be useful in the treatment of gastrointestinal disorders, cardiovascular regulation, motor disorders, endocrine disorders, vasospasm and sexual dysfunction. The compounds are 5HT.sub.1B and 5HT.sub.1D antag...