A pyrazoloquinoline derivative having the formula (I): ##STR1## wherein R.sup.1, R.sup.2, and R.sup.3 independently represent a hydrogen atom or a lower alkyl group; R.sup.4 represents a hydrogen atom, a lower alkyl group, a halogen-substituted lower alkyl group, or a lower alkoxycarbonyl group; the dotted line means that the pyrazole ring has two conjugated double bonds; and R.sup.4 is bonded to the nitrogen atom at the 1-position or 2-position, or pharmacologically acceptable salts thereof. Th...

This invention relates to a continual quick service valve device operative sequentially with each successive brake pipe pressure reduction over the entire service application range of brake pipe pressure reductions to effect "quick service" transmission through a train brake pipe of a pressure reduction wave. Fluid under pressure heretofore released from the quick action chamber of a conventional brake control valve device to atmosphere upon effecting a service reduction of brake pipe pressure i...

This invention relates to novel substituted derivatives of 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid and analogs thereof, which are useful for the treatment of hypertension, as well as, novel pharmaceutical compositions and methods of use.

Imidazo-containing compounds (e.g., imidazonaphthyridines, imidazopyridines, imidazoquinolines, and imidazote-trahydroquinolines) with an alkoxy substituent at the 1-position, pharmaceutical compositions containing the compounds and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

A release graduating valve for freight brake control is provided for a railcar having a pneumatic control valve, emergency and auxiliary reservoirs each normally charged with pressurized fluid from a brake pipe and a fluid pressure activated brake cylinder device for applying the brakes on the railcar. A selectively operable release graduating valve can include a graduated release valve and a changeover valve which selectively interposes the graduated release valve to exhaust brake cylinder pres...

According to the invention, the existence of residual pressure in the braking system is determined by means of continuous rough monitoring of the pressure in said system. If the existence of said residual pressure is established, then a fine monitoring process is carried out several times, whereby a pressure relieving body in the braking system is opened and sensed in order to determine whether the actual pressure is decreasing and if so to what extent.

This invention relates to a cycling-type continual quick service valve device which embodies therein a quick service valve means that comprises two valves each operatively connected to an abutment subject to fluid under pressure supplied from a train brake pipe through a first restriction to a chamber on one side thereof and subject to fluid under pressure supplied from the brake pipe to a chamber at the opposite side and to a quick service chamber via two restrictions arranged in parallel and i...

Pyrazolopyridin-4-amines, pyrazoloquinolin-4-amines, pyrazolonaphthyridin-4-amines, and 6,7,8,9-tetrahydropyrazoloquinolin-4-amines, pharmaceutical compositions containing the compounds, intermediates, methods of making, and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.

Disclosed are polymer having antistatic properties and having a multilayered structure comprising an innermost layer, a second layer, a third layer and an outermost layer; processes for preparing the multilayered polymer; and an antistatic resin composition comprising a thermoplastic resin and the multilayered polymer.

A valve assembly for use with spring-set air-release vehicle parking brakes comprises a particular arrangement of conventional components providing desired spring brake operational characteristics heretofore requiring costly, complex specially-designed units. The valve assembly typically employs a plurality of interconnected check valves in combination with pressure protection and quick release valves to provide the desired characteristics. These include a system whereby at startup pressurized a...