A pharmaceutical composition for oral delivery of a peptide is in the form of a lamination having at least two layers. The first layer of the lamination includes at least one pharmaceutically acceptable pH-lowering agent. The second layer includes a therapeutically effective amount of the peptide. The composition also includes at least one absorption enhancer effective to promote bioavailability of the peptide, which is preferably in the second layer, and an enteric coating surrounding the lamin...

A hand-held, manually-operated, sanding tool for use with a replaceable sheet-like abrasive material, such as sandpaper, includes a base member and clamping mechanisms pivotally connected with opposed ends of the base member. The clamping mechanisms include tensioning members arranged to slidably engage angled contact surfaces provided on the ends of the base member opposite the clamping mechanisms to tighten the sheet-like abrasive material as it is installed on the tool.

The present invention provides a process for making 3-hydroxyalkanenitriles comprising the steps of reacting an alkenylnitrile, wherein the alkenylnitrile is an alkenyl-2-nitrile or an alkenylnitrile which under reaction conditions isomerizes to form an alkenyl-2-nitrile, in the presence of a base with benzyl alcohol to form a 3-benzyloxyalkanenitrile adduct and then partially hydrogenating the adduct in the presence of a trace amount of HCl to form the 3-hydroxyalkanenitrile or fully hydrogenat...

An encapsulation process employs an aqueous dispersion of silica having a particle size not substantially greater than 100 nm. An emulsion is formed by high shear mixing of the silica dispersion with the material to be encapsulated and the emulsion is gelled. The process allows hydrophobic materials to be encapsulated in structures which have a high loading of the material and a good degree of imperviousness in the presence of other materials such as surfactants and mineral oils. Using the proce...

In a plate clamping device of a printing press for clamping a plate by a bottom clamping rail and a pressure plate, chips hardened to form serrations inclined in the lateral direction of a plate clamp so as to bite the plate in the direction of slipping-off of the plate are embedded in the clamp surfaces of the bottom clamping rail and the pressure plate such that the serrations on the bottom clamping rail side and the pressure plate side are inclined in opposite directions. Thus, the plate can ...

The invention relates to an oral administration form for pyridin-2-ylmethylsulfinyl-1H-benzimidazoles and their salts, which comprises the active compound together with tablet disintegrants and is provided with a film coating customary per se for sustained-release compositions.

An abrasive wheel with improved structure comprises: an abrasive component, an adapting ring received by the combining hole in the central region of the abrasive component, two covers which are posited about both mounting surfaces respectively, wherein each cover at the surface thereof facing to the corresponding mounting surface has a pressing segment and a blocking segment, wherein each pressing segment comprises a plurality of teeth so that after the disclosed abrasive wheel is assembled, the...

An encapsulation process employs an aqueous dispersion of silica having a particle size not substantially greater than 100 nm. An emulsion is formed by high shear mixing of the silica dispersion with the material to be encapsulated and the emulsion is gelled. The process allows hydrophobic materials to be encapsulated in structures which have a high loading of the material and a good degree of imperviousness in the presence of other materials such as surfactants and mineral oils. Using the proce...

Rapidly releasable attachment of an abrasive disk to a rotary grinder is provided by fitting the disk with a disk retention adapter which clamps onto the disk and is provided with retention means extending from the non-abrasive bearing surface, a also providing a lock-nut assembly for mounting on the drive shaft of the rotary grinder which comprises a number of detents and detent access slots which permit the retention means to be inserted into the slots and, by a simple axial rotation move the ...

An apparatus for supporting an abrasive material includes a flexible base defined by a first end and a second end, and by a lower surface which supports the abrasive material and an upper surface opposite the lower surface. The flexible base is fabricated from a resilient material so as to assume an essentially flat shape when the ends of the flexible base are not acted on by external forces. A front frame is member attached to the flexible base proximate the first end, and a rear frame member i...