A vitamin K mixture is used in a topical application for the treatment of blood vessel disorders of the skin which include, but are not limited to, actinic and iatrogenic purpura, lentigines and other vascular problems of the skin and subcutaneous tissue. The formulation of the mixture includes a number of the following substances: vitamin K, 95% ethyl alcohol SD40, isopropyl alcohol 99%, benzyl alcohol, lecithin granules, isopropyl palmitate NF, propyl paraben, methyl paraben, Pluronic F-127 NF...

With an object of providing an agent for treating hepatic disease by inhibiting occurrence of hepatic disease, in particular portal venous invasion, there is disclosed an agent for treating or preventing hepatic disease containing menatetrenone as an active ingredient thereof. This agent for treating or preventing hepatic disease is effective against hepatic cancer, in particular DCP (des-.gamma.-carboxy prothrombin) positive hepatic cancer. Moreover, the agent for treating or preventing hepatic...

A method of reducing hyperlipemia in warm-blooded animals by administration of an effective amount of 2-[(3,4-dimethoxy-benzoyl)-methyl]-2-hydroxy-1,3-dioxoIndone.

Purpurogallin and its mono- and di-glucosides are useful as cytoprotective agents. Patient-administrable compositions for addition to a patient's blood to minimize oxyradical damage caused by ischemia-reperfusion injury that may result in various surgical procedures, and comprising purpurogallin or glucosides thereof, and uses thereof, are described.

Disclosed are compounds of formula ##STR1## wherein F represents: ##STR2## or a pharmaceutically acceptable salt. The compounds are useful in treating hyperproliferative skin disease, allergic reactions and inflamation.

A combination of Vitamin C and a quinone used as a supplemental treatment for a cancer patient. The combination may be administered before, during and after the patient undergoes a conventional cancer treatment protocol. The combination may be administered orally, intravenously, or intraperitoneally. Oral administration may be in the form of capsules containing a predetermined ratio of Vitamin C to Vitamin K.sub.3. The supplemental treatment is effective to inhibit metastases of cancer cells and...

New indene derivative, obtainable from etiolated seedlings of Adlay and shown by Formulas (1) and (2) given below, have antimicrobial effects and can serve as effective components of antimicrobial agents: ##STR1##

Malignant melanoma cells spontaneously generate reactive oxygen species (ROS) that promote constitutive activation of the transcription factor nuclear factor-kB (NF-kB). Although antioxidants and inhibitors of NAD(P)H oxidases significantly reduce constitutive NF-kB activation and suppress cell proliferation, the nature of the enzyme responsible for ROS production in melanoma cells has not been determined. To address this issue, we now have characterized the source of ROS production in melanoma ...

Methods and compositions for treatment of, or protection from, neuropathy resulting from reperfusion injury upon reversal of an ischemic condition, comprising treatment or prophylactic treatment of the patient with an antagonist of the type 3 ryanodine receptor, such that a rise in cytosolic Ca.sup.2+ concentration is prevented. Therapeutic compositions containing dantrolene or aminodantrolene are administered to the patient to prevent a rise in cytosolic Ca.sup.2+ that would otherwise result in...

Methods for treating, preventing, or inhibiting diseases and disorders associated with inflammation, cell-proliferation, and pain comprising the administration of a compound having the structural formula ##STR1## wherein R.sub.1 is a hydrogen, alkyl, aryl, hydroxyalkyl, cycloalkyl, cycloalkenyl, carboxylic acid, alkylamino or amide group having from 2 to 20 carbon atoms, R.sub.2, R.sub.3, and R.sub.4 are each independently hydrogen or an acyl residue having from 1 to 6 carbon atoms, R.sub.5 is h...