Methods are provided for the identification, biochemical characterization and therapeutic use of agents which impact PTEN, p53, PI-kinase and AKT mediated cellular signaling.

Methods are provided for the identification, biochemical characterization and therapeutic use of agents which impact PTEN, p53, PI-kinase and AKT mediated cellular signaling.

Described herein are methods for producing recombinant forms of asparaginase derived from Wolinella succinogenes. In addition, methods for covalent modification of proteins, including asparaginases, by acylation are also provided. Certain embodiments provide for epitopic-labeling of the amino terminus of W. succinogenes asparaginase. Additional embodiments concern methods for the therapeutic utilization of the native, homotetrameric form of W. succinogenes asparaginase, as well as the use of epi...

Described herein are methods for producing recombinant forms of asparaginase derived from Wolinella succinogenes. In addition, methods for covalent modification of proteins, including asparaginases, by acylation are also provided. Certain embodiments provide for epitopic-labeling of the amino terminus of W. succinogenes asparaginase. Additional embodiments concern methods for the therapeutic utilization of the native, homotetrameric form of W. succinogenes asparaginase, as well as the use of epi...

The invention provides prodrugs of inhibitors of PI-3 kinase. The compounds are LY294002 and analogs thereof comprising a reversibly quaternized amine.

The invention provides novel prodrugs of inhibitors of PI-3 kinase. The novel compounds are LY294002 and analogs thereof comprising a reversibly quaternized amine.

Automatic level calibration apparatus for transmitting data from a cable television terminal to the headend of a cable television system comprises programmable transmitter apparatus of the terminal, programmable receiving apparatus at the headend and a calibration controller. Responsive to an addressed command from the headend, the programmable transmitter apparatus returns a sequence of levels at a particular calibration frequency. The programmable receiver apparatus determines an indication of...

A method of transferring a data message from a remote unit to a central location is provided. A plurality of data channels is selected for transmitting the data message from the remote unit to the central location. At least one random transmit time is generated for transmitting the data message for each of the plurality of data channels. The data message is transmitted over the plurality of data channels at the transmit times. An apparatus for transferring a data message from a remote unit to a ...