Provided are assays to detect ADAMTS13 activity using peptide substrates. These assays can be used for diagnostic applications and to evaluate treatment of thrombotic thrombocytopenic purpura (TTP). Also provided is a novel form of ADAMTS13 found on platelets.

The invention is directed in part to a purified form of stabilized activated thrombin-activatable fibrinolysis inhibitor (TAFIa). The invention is further directed to a method of producing stabilized TAFIa. The invention is also directed to methods for therapeutic use of stabilized TAFIa such as in the treatment, prevention or management of diseases via an anti-coagulant effect. The invention is also directed to methods for therapeutic use of inhibitors of TAFIa such as in the treatment, prevent...

The invention relates to a diagnostic assay for selectively measuring levels of the 35kD form of thrombin-activatable fibrinolysis inhibitor (TAFIa or TAFIai), or a derivative or variant thereof, but not the TAFI proenzyme (TAFI) or the N-terminal activation peptide of TAFI.

Cheese curd is compressed into blocks by feeding the curd into the top of a hollow tower having a perforated lining while the tower is at a sub-atmospheric pressure to form a pillar of curd supported on a guillotine blade at the bottom of the tower, the guillotine blade is then withdrawn, the pillar of curd lowered by an elevator, and the guillotine blade returned to the closed position so as to cut off a block of curd from the bottom of the pillar of curd. The tower comprises a tubular casing, ...

A multiprocessor system includes a distributed bus arbitration system in which bus arbitration takes place simultaneously on each of the multiple processors connected to the bus. Each processor has a local arbitrator of common configuration with the other local arbitrators and a dedicated request line. Each local arbitrator is connected to each dedicated request line to monitor signals on lines indicative of requests for mastership of the bus by the processors. Since each local arbitrator is of ...

Process and apparatus for recovering clean water and solids from aqueous solids are disclosed. Aqueous solids are mixed with a low viscosity, relatively volatile, water-immiscible light fluidizing oil to obtain a mixture which will remain fluid and pumpable after removal of essentially its entire water content. The mixture of solids, water and fluidizing oil is subjected to a dehydration step by means of a plurality of mechanical vapor recompression evaporators operating in staged array whereby ...

Process and apparatus for recovering residual oil from solids previously substantially dehydrated by a process wherein a slurry of water-wet solids in oil is subjected to a heat evaporation step to substantially remove the water. The oil is then largely expressed from the solids after which the solids still containing some oil as residual oil are extracted with a relatively low viscosity and relatively volatile water-immiscible light oil. The light oil-laden solids are then brought into direct c...

An apparatus for removing light oil from solids. The invention is particularly applicable to the removal of residual light oil from solids obtained in an apparatus where aqueous solids are mixed with a light fluidizing oil and subjected to dehydration by heat evaporation. Aqueous solids are mixed with a low viscosity, relatively volatile, water-immiscible light fluidizing oil in a fluidizing tank to obtain a mixture which will remain fluid and pumpable after removal of essentially its entire wat...

Process and apparatus for removing light oil from solids. The invention is particularly applicable to the removal of residual light oil from solids obtained in a process where aqueous solids are mixed with a light fluidizing oil and subjected to dehydration by heat evaporation. Aqueous solids are mixed with a low viscosity, relatively volatile, water-immiscible light fluidizing oil to obtain a mixture which will remain fluid and pumpable after removal of essentially its entire water content. The...

An improved process and apparatus for recovering clean water from dilute solutions of waste solids. A dilute stream of waste solids is concentrated by evaporation and the evaporated water is condensed and recovered. The waste solids in concentrated solution are mixed with oil and subject to further drying by evaporation. Again the evaporated water is condensed and recovered. If desired, the waste solids may be separated from the oil which may then be recycled.