A process for preparing 1.alpha.-hydroxylated calciferols is described. Intermediates used in the process are also provided.

A process for preparing 1.alpha.-hydroxylated calciferols is described. Intermediates used in the process are also provided.

Disclosed is an improved process for the oxidation of certain .DELTA..sup.5 -steroids to the corresponding 7-keto-.DELTA..sup.5 -steroids by use of a chromium trioxide-pyrazole oxidant (oxidizing agent).

A method for preparing 9.beta., 10.alpha.-cholesta-5,7-diene-3.beta.,25 diol and 25-hydroxyprevitamin D.sub.3 by irradiation.

Anti-inflammatory agents of the formula I: ##SPC1## wherein R is lower alkyl, cycloalkyl or cycloalkylalkyl, R' is a radical of the formula ##SPC2## in which Y and Y' are hydrogen, lower alkyl, lower alkoxy, halo or trifluoromethyl, or a radical of the formula ##SPC3## in which Y" is hydrogen, halo or alkyl, Are prepared by cyclizing a compound of formula II ##SPC4## in which R and R' are as defined above, with phosgene.

Anti-inflammatory and analgesic agents of the formula I: ##SPC1## wherein n is 2 to 7, R.degree. is lower alkyl, m is 0, 1 or 2, R is lower alkyl, alkenyl, cycloalkyl, cycloalkylalkyl or phenyl, R' is a radical of the formula ##SPC2## In which Y and Y' are the same or different and represent hydrogen, lower alkyl, lower alkoxy, halo of atomic weight of 19 to 36 or one of Y and Y' is trifluoromethyl while the other is hydrogen, or a radical of the formula ##SPC3## In which Y" is hydrogen, fluorin...

Substituted-4-phenyl-5H-cycloalkano[d] pyrimidines e.g., 6,7,8,9-tetrahydro-2-(4'-methyl-1'-piperazyl)-4-phenyl-5H-cyclopenta[d]pyr imidine, are prepared by treating a corresponding 2-halo-substituted-4-phenyl-5H-cycloalkano[d]pyrimidine with an amine and are useful as anti-inflammatory agents.

A method for preparing 25-hydroxycholesterol and novel intermediates.

A new method of preparing 3.alpha.,5.alpha.-cyclo-6.beta.-alkoxy-.DELTA..sup.22 -25-oxy or acyloxy bisnorcholestane and analogues which involves reacting a bisnorcholanaldehyde with an ylide. Novel cholestanes and i-ethers are also claimed.

Benzocycloheptaoxazolones are prepared by a multi-step process starting with a lower alkyl ester of a 3-oxo-5-phenylvaleric acid. The compounds are useful as anti-inflammatories and as intermediates in the preparation of pharmaceutically useful compounds.