Compounds of the formula ##STR1## or the salts thereof, wherein each Z is independently N or CH, but one Z must be N; wherein n.sup.1 is 1 and n.sup.2 is 0 or 1; X.sup.1 and X.sup.2 are linkers; Ar represents one or two substituted or unsubstituted aromatic or heteroaromatic rings, and Cy represents one or two substituted or unsubstituted aliphatic cyclic or heterocyclic rings, or consists of one substituted or unsubstituted aliphatic cyclic or heterocyclic ring and one substituted or unsubstitu...

Compounds of the formula ##STR1## and their salts, wherein Cy represents cyclohexyl; Y is CH.dbd.CH.PHI., CH.PHI..sub.2, .PHI. or Cy, X is trivalent straight-chain alkylene (3-10C) or trivalent straight-chain 1-alkenylene (3-10C) optionally substituted by oxo at the C adjacent N when n is 0 and Y is .PHI..sub.2 CH; and is otherwise trivalent straight-chain alkylene (5-10C) or trivalent straight-chain 1-alkenylene (5-10C) optionally substituted by oxo at the C adjacent N; Z is N, NCO, CHNCOR.sup....

Compounds of the formula ##STR1## and their salts, wherein Cy represents cyclohexyl; Y is CH.dbd.CH.PHI., CH.PHI..sub.2, .PHI. or Cy, X is trivalent straight-chain alkylene (3-10C) or trivalent straight-chain 1-alkenylene (3-10C) optionally substituted by oxo at the C adjacent N when n is 0 and Y is .PHI..sub.2 CH; and is otherwise trivalent straight-chain alkylene (5-10C) or trivalent straight-chain 1-alkenylene (5-10C) optionally substituted by oxo at the C adjacent N; Z is N, NCO, CHNCOR.sup....

Compounds of the formula ##STR1## or salts thereof, wherein the variable are as defined herein are useful as calcium channel blockers.

Compounds of the formula ##STR00001## and their salts, wherein Cy represents cyclohexyl; Y is CH.dbd.CH.PHI., CH.PHI..sub.2, .PHI. or Cy, X is trivalent straight-chain alkylene (3 10C) or trivalent straight-chain 1-alkenylene (3 10C) optionally substituted by oxo at the C adjacent N when n is 0 and Y is .PHI..sub.2CH; and is otherwise trivalent straight-chain alkylene (5 10C) or trivalent straight-chain 1-alkenylene (5 10C) optionally substituted by oxo at the C adjacent N; Z is N, NCO, CHNCOR.s...

Sequences and partial sequences for three types of mammalian (human and rat sequences identified) T-type calcium channel subunits which we have labeled as the .alpha..sub.1G, .alpha..sub.1H and .alpha..sub.1I subunits are provided. Knowledge of the sequence of these calcium channel permits the localization and recovery of the complete sequence from human cells, and the development of cell lines which express the novel calcium channels of the invention. These cells may be used for identifying com...

Sequences and partial sequences for three types of mammalian (human and rat sequences identified) T-type calcium channel subunits which we have labeled as the .alpha..sub.1G, .alpha..sub.1H and .alpha..sub.1I subunits are provided. Knowledge of the sequence of these calcium channel permits the localization and recovery of the complete sequence from human cells, and the development of cell lines which express the novel calcium channels of the invention. These cells may be used for identifying com...

Sequences and partial sequences for three types of mammalian (human and rat sequences identified) T-type calcium channel subunits which we have labeled as the .alpha..sub.1G, .alpha..sub.1H and .alpha..sub.1I subunits are provided. Knowledge of the sequence of these calcium channel permits the localization and recovery of the complete sequence from human cells, and the development of cell lines which express the novel calcium channels of the invention. These cells may be used for identifying com...

Derivatives of urea that contain piperazine rings and additional substitution with aromatic groups are effective in ameliorating conditions associated with unwanted calcium ion channel activity.

A specific amino acid sequence proximal to the carboxy terminus of P/Q type ion channels has been shown to mediate, through binding to the Homer protein, the expression of the gene encoding syntaxin-1A. This region of the P/Q type calcium ion channel provides peptides that can be used in screening assays for compounds that modulate the central nervous system.