Haemophilus adhesion and penetration proteins, nucleic acids, vaccines and monoclonal antibodies are provided.

Haemophilus adhesion and penetration proteins, nucleic acids, vaccines and monoclonal antibodies are provided.

Haemophilus adhesion and penetration proteins, nucleic acids, vaccines and monoclonal antibodies are provided.

Haemophilus adhesion and penetration proteins, nucleic acids, vaccines and monoclonal antibodies are provided.

Haemophilus adhesion and penetration proteins, nucleic acids, vaccines and monoclonal antibodies are provided.

The invention relates to novel Haemophilus adhesion proteins, nucleic acids, and antibodies.

High molecular weight surface proteins of non-typeable Haemophilus influenzae which exhibit immunogenic properties and genes encoding the same are described. Specifically, genes coding for two immunodominant high molecular weight proteins, HMW1 and HMW2, have been cloned, expressed and sequenced, while genes coding for high molecular proteins HMW3 and HMW4 have been cloned, expressed and partially sequenced.

The invention relates to novel Haemophilus adhesion proteins, nucleic acids, and antibodies.

Nucleic acids encoding all or part of a Yersinia ail gene are provided. The nucleic acid comprises at least 50 base pairs of a Yersinia ail gene in isolated form or consists or a fragment consisting essentially of at least 50 base pairs but not more than 50 kilo base pairs of a Yersinia ail gene. Such nucleic acids can also be operably linked to transcriptional and translational initiation and termination sequences which are functional in a microorganism host.

Novel methods and microorganisms are provided, where novel genetic mammalian cell invasive capability is imparted to a microorganism by the introduction of an exogenous ail or hil gene. The resulting organisms are then capable of binding to mammalian cells and are transferred to the cytoplasm. Other novel genetic capabilities may be imparted to the unicellular microorganism, which may serve as a vaccine for one or more pathogens or may introduce genetic capabilities or foreign molecules into a m...