Substituted dialkanolamines, oxazine and sulfur analogs thereof, useful in treating shipping fever syndrome in mammals are disclosed having the formula: ##STR1## wherein: Ar is ##STR2## Z is oxygen or sulfur; R is selected from hydrogen, loweralkyl or ##STR3## R.sup.1 R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6 and R.sup.7 are selected from hydrogen or loweralkyl; and ##STR4## when taken together may form a lowercycloalkyl ring or R.sup.5 with --ZR.sup.2 when taken together may form a 5-membered...