A process for obtaining a consensus protein from a group of amino acid sequences of a defined protein family, proteins and polynucleotides so obtained, and compositions containing such proteins.

A process for obtaining a consensus protein from a group of amino acid sequences of a defined protein family, proteins and polynucleotides so obtained, and compositions containing such proteins.

A process for obtaining a consensus protein from a group of amino acid sequences of a defined protein family, proteins and polynucleotides so obtained, and compositions containing such proteins.

Described are rapid and highly efficient procedures for the total synthesis of linear, double stranded DNA sequences in excess of about 200 base pairs in length, which sequences may comprise entire structural genes. Novel sequences are prepared from two or more DNA subunits provided with terminal regions comprising restriction endonuclease cleavage sites facilitating insertion of subunits into a selected vector for purposes of amplification during the course of the total assembly process. The to...

Described are rapid and highly efficient procedures for the total synthesis of linear, double stranded DNA sequences in excess of about 200 base pairs in length, which sequences may comprise entire structural genes. Novel sequences are prepared from two or more DNA subunits provided with terminal regions comprising restriction endonuclease cleavage sites facilitating insertion of subunits into a selected vector for purposes of amplification during the course of the total assembly process. The to...

New failure detector mechanisms particularly suitable for use in asynchronous distributed computing systems in which processes may crash and recover, and two crash-recovery consensus mechanisms, one requiring stable storage and the other not requiring it. Both consensus mechanisms tolerate link failures and are particularly efficient in the common runs with no failures or failure detector mistakes. Consensus is achieved in such runs within 3.quadrature. time and with 4n messages, where .quadratu...

Disclosed are analogs of human leukocyte interferon which predominantly include those amino acid residues which are common to all naturally-occurring human leukocyte interferon subtype amino acid sequences and which include, at one or more of those positions where there is no amino acid common to all subtypes, an amino acid which predominantly occurs at that position and in no event include any amino acid residue which is not extant in that position in at least one naturally-occurring subtype.

A consensus DNA sequence has been determined for the BRCA1 gene. As has been seven polymorphic sites and their rates of occurrence in normal BRCA1 genes. The consensus gene BRCA1.sup.(omi) and the seven polymorphic sites will provide greater accuracy and reliability for genetic testing. One skilled in the art will be better able to avoid misinterpretations of changes in the gene, determine the presence of a normal gene, and of mutations, and to classify tumors.

A computational method maximizing open reading frame length in an assembly consensus sequence is provided. Systems employing the method are also provided.

An embodiment of a method of seeking consensus among computer processes begins with a first step of saving a new timestamp in a timestamp array for a particular process. The method continues with a second step of determining whether a most recent entry in a decision array includes a previously established consensus decision. In a third step, if the most recent entry does not include the previously established consensus decision, the method saves a proposed decision as a consensus decision. Other...