An object of the present invention is to provide compounds which have antitumor activity and do not change cytomorphosis. Disclosed are compounds represented by formula (I) and a pharmaceutically acceptable salts and solvates thereof and pharmaceutical compositions comprising said compounds: ##STR1## wherein X and Z each independently represent CH or N; R.sup.1 to R.sup.3 represent H, substituted alkoxy, unsubstituted alkoxy or the like; R.sup.4 represents H; R.sup.5 to R.sup.8 represent H, halo...

A compound of the formula (I) ##STR1## in which R.sup.1 is --OR.sup.11, --SR.sup.11, --SOR.sup.11, --SO.sub.2 R.sup.11, --NHR.sup.11, or --NR.sup.12 R.sup.13 , and R.sup.11, R.sup.12, and R.sup.13 are as defined broadly in the text. R.sup.2 is H, C.sub.1 -C.sub.6 alkyl, carbamoyl, or an ester group. R.sup.3 is thienyl, pyridyl optionally substituted by halogen or C.sub.1 -C.sub.6 alkoxy; naphthyl optionally substituted by C.sub.1 -C.sub.6 alkoxy; dioxane fused phenyl; dioxacyclopentane fused phe...

An object of the present invention is to provide compounds which have antitumor activity and do not change cytomorphosis. Disclosed are compounds represented by formula (I) and a pharmaceutically acceptable salts and solvates thereof and pharmaceutical compositions comprising said compounds: ##STR00001## wherein X and Z each independently represent CH or N; R.sup.1 to R.sup.3 represent H, substituted alkoxy, unsubstituted alkoxy or the like; R.sup.4 represents H; R.sup.5 to R.sup.8 represent H, ...

Benzotriazocine derivatives represented by the formula ##SPC1## Wherein X, represents a hydrogen atom, a halogen atom or an alkyl group, R.sup.1 represents a dialkylaminoalkyl group or an aralkyl group, and R.sup.2 represents a hydrogen atom or a halogenoacetyl group having useful pharmaceutical activities on the central nervous system, and processes for preparing the benzotriazocine derivatives are disclosed.

A novel rearrangement of 1,2-dihydro-2-(3-indolyl)-1-[2-(1-pyrrolinyl)]quinolines provide 9-(3-indolylvinyl)-1,2,3,9-tetrahydropyrrolo[2,1-b]quinazolines which have utility as anti-thrombogenic and/or anti-inflammatory agents. The pyrroloquinazolines are also useful as intermediates in view of their capability of being converted into 3-(indolylethyl)pyrroloquinazolines which have diuretic properties and quaternary indolylvinylpyrroloquinazolines which have anti-inflammatory properties.

Esters of N-hydroxy-N-9-xanthenylureas and substituted derivatives thereof useful in the treatment of peptic ulcer.

Derivatives of digoxigenin which are either unlabeled or radioiodinated having the following structural formula: ##SPC1## Wherein R' is hydroxyl or acetoxy; B is succinyl, phthaloyl, maleyl or fumaryl, preferably succinyl, and X is hydroxyl or alkali metal salt thereof; a protein conjugate; a peptide conjugate; or an amino acid or amino acid ester radical. The radiolabeled compounds are used in the radioimmunological assay of digoxin. The preferred compound is radioiodinated 3-succinyl digoxigen...

The invention provides novel compounds of the formula: ##SPC1## And salts thereof, in which R.sup.1 is n-butyl, cycloalkyl having five to eight ring carbon atoms, cyclohexenyl, 4-methylcyclohexyl, 4,4-dimethylcyclohexyl, 4-methoxycyclohexyl, 2,5-endomethylenecyclohexyl or endoethylenecyclohexyl, R.sup.2 is hydrogen or methoxy, methyl, bromine or chlorine in position four or in position five, R.sup.3 is methyl or hydrogen, R.sup.4 and R.sup.5 are each hydrogen or methyl but not both methyl at the...

Xanthone derivatives of the formula: ##SPC1## In which X represents a carboxyl or 5-[1H]-tetrazolyl group; and R.sub.1 and R.sub.2 which may be the same or different each represent a hydrogen atom, an alkyl group containing from 1 to 4 carbon atoms, a nitro group, a halogen atom or a group of the formula --NR.sub.3 R.sub.4 or OR.sub.3 or NR.sub.5 SO.sub.2 R.sub.6, (in which the groups R.sub.3 and R.sub.4 which may be the same or different each represent a hydrogen atom, a phenyl group, a benzyl ...

Novel compounds useful in preventing the coagulation of blood are represented by the formula ##SPC1## Wherein n is a positive whole integer of from 3 to 7; Z represents a straight or branched divalent alkylene chain of from two to six carbon atoms which is substituted with one phenyl radical on any one of the six carbon atoms with the proviso that the alkylene chain carbon atom adjacent to the exocyclic nitrogen must have a least one hydrogen atom attached to it; and pharmaceutically acceptable ...