Device for slip forming concrete pathways such as golf cart paths, driveways, sidewalks and the like. A concrete slip form is continuously moved forward to form concrete aggregate into a smooth, uniform member, and comprises a mold member having an open end for receiving the concrete aggregate and a lower end for discharging the aggregate; means for moving the mold member to effect the discharge of the concrete member; means for forming and contouring the ground surface prior to pouring the aggr...

The present invention provides metal/polymer composites including a plastic substrate having longitudinally extending conductive members, adapted to make bonded electrical connections to an array of closely spaced conductive terminal pads. In general terms, the metal/polymer composites include a thin, flexible sheet-like plastic substrate having a plurality of longitudinally extending, regularly spaced, metal pathways or members on one major surface thereof.

Experimental and analytical methods enable reconstruction of signal transduction networks from gene expression profiles. Signal transduction pathways can be reverse-engineered by 1) experimentally manipulating individual genes, 2) generating cellular expression profiles, and 3) analyzing for common patterns among these profiles. Analysis of patterns among profiles permits reconstruction of pathways and networks of interrelationships among genes and their products.

The present invention provides metal/polymer composites including a plastic substrate having longitudinally extending conductive members, adapted to make bonded electrical connections to an array of closely spaced conductive terminal pads. In general terms, the metal/polymer composites include a thin, flexible sheet-like plastic substrate having a plurality of longitudinally extending, regularly spaced, metal pathways or members on one major surface thereof.

Experimental and analytical methods enable reconstruction of signal transduction networks from gene expression profiles. Signal transduction pathways can be reverse-engineered by 1) experimentally manipulating individual genes, 2) generating cellular expression profiles, and 3) analyzing for common patterns among these profiles. Analysis of patterns among profiles permits reconstruction of pathways and networks of interrelationships among genes and their products.

The invention provides methods and compositions for inducing and detecting signal transduction through LDL receptors, including specifically detecting a stress that alters a functional interaction of a low density lipoprotein (LDL) receptor binding polypeptide with an LDL receptor interaction domain, by (a) introducing a predetermined stress into a system which provides a physical interaction of an LDL receptor binding polypeptide with an LDL receptor intracellular binding polypeptide interactio...

The present invention provides methods for identifying and representing the biological pathways of drug action on a cell by: (i) measuring responses of cellular constituents to graded exposures of the cell to a drug of interest; (ii) measuring the responses of cellular constituents to perturbations in one or more biological pathways of the cell; and (iii) scaling a combination of the measured pathway responses to fit the measured drug responses best according to an objective measure. In alternat...

An integrated prefabricated furniture system is provided for fitting-out a building room of the type having a generally open plan interior and having at least one utility source. The furniture system includes a plurality of horizontal beam segments interconnected in an end-to-end fashion to form a rigid overhead framework configured to be positioned above the floor surface. A plurality of overhead support columns each have an upper portion rigidly connected with the overhead framework, and a low...

Spiral implant for organ pathways, in particular for blood vessels, which is formed from a primary spiral made of metal or a primary tube made of an elastic synthetic material whose anterior end is closed and whose cross-section at a distance of 0.5 to 2 mm from the other end of the primary spiral or primary tube is modified for a distance of 0.01 to 10 mm in order to make it possible to reposition the implant. The force required to displace the primary shape on the guide wire serving as an inse...

Methods for manipulating carbohydrate processing pathways in cells of interest are provided. Methods are directed at manipulating multiple pathways involved with the sialylation reaction by using recombinant DNA technology and substrate feeding approaches to enable the production of sialylated glycoproteins in cells of interest. These carbohydrate engineering efforts encompass the implementation of new carbohydrate bioassays, the examination of a selection of insect cell lines and the use of bio...