A process for the separation of at least one isomer from a mixture of isomers of a tetrahydropyran-2-one, having at least two chiral centres which comprises selective reaction of at least one isomer with a reagent catalysed by a hydrolase enzyme whereby at least one isomer is preferentially converted into a distinct chemical species from the other isomers so that it is susceptible of separation by an appropriate chemical or physical separation process in which the tetrahydropyran-2-one is of For...

A process for the separation of at least one isomer from a mixture of isomers of a tetrahydropyran-2-one, having at least two chiral centers which comprises selective reaction of at least one isomer with a reagent catalyzed by a hydrolase enzyme whereby at least one isomer is preferentially converted into a distinct chemical species from the other isomers so that it is susceptible of separation by an appropriate chemical or physical separation process in which the tetrahydropyran-2-one is of For...

A process for the separation of at least one isomer from a mixture of isomers of a tetrahydropyran-2-one, having at least two chiral centres, which comprises selective reaction of at least one isomer with a reagent catalysed by a hydrolase enzyme whereby at least one isomer is preferentially converted into a distinct chemical species from the other isomers so that it is susceptible of separation by an appropriate chemical or physical separation process in which the tetrahydropyranone is of Formu...

A process for the separation of at least one isomer from a mixture of isomers of a tetrahydropyran-2-one, having at least two chiral centers which comprises selective reaction of at least one isomer with a reagent catalyzed by a hydrolase enzyme whereby at least one isomer is preferentially converted into a distinct chemical species from the other isomers so that it is susceptible of separation by an appropriate chemical or physical separation process in which the tetrahydropyran-2-one is of For...

The invention relates to a novel 2H-1-pyran-2-ones of general formula (I), ##STR1## wherein R.sup.1 represents an alkyl radical with 2-5 C atoms, a cycloakyl radical with 4-6 C atoms, a cycloalkyl radical with 4-8 C atoms or an alkoxy alkyl radical with a total of 3-5 C atoms and R.sup.2 represents a 2-(3, 4-methylene dioxyphenyl) radical or a 2-phenyl ethenyl radical substituted with R.sup.3, R.sup.4 and R.sup.5 in positions 3, 4 and 5, whereby independently from each other R.sup.3 and R.sup.5 ...

Novel 3-substituted-4-aminoalkoxy-5,6-condensed ring-2-pyranones are disclosed as having utility as pharmacologically active compounds, in particular vasodilatory, hypotensive, anti-ischemic and anti-tussive activity. The compounds may be 3-phenyl-4-morpholinoalkoxy-coumarins. Administration may be by the oral or parenteral route. Intermediates useful in the production of these compounds are also disclosed.

Compounds of the formula ##STR1## wherein R.sub.1 is methyl or R.sub.1 R.sub.1 is oxygen; R.sub.2 is alkyl or halogen substituted phenyl alkyl; and R.sub.3 is hydrogen, loweralkyl, loweralkenyl or loweralkynyl. The compounds of this invention are useful as analgesics and tranquilizers.

Compounds of the formula ##STR1## wherein R.sub.1 is methyl or R.sub.1 R.sub.1 is oxygen; R.sub.2 is alkyl or halogen substituted phenyl alkyl; and R.sub.3 is hydrogen, loweralkyl, loweralkenyl or loweralkynyl.

Cyclohexane-1,3-diones of the formula ##STR1## having up to 24 carbon atoms are prepared in admixture with 6-alkyl-3,4-dihydro-2-pyranones of the formula ##STR2## having up to 24 carbon atoms, in which formulae the radicals R and R' may be identical or different and represent each a hydrogen atom, an alkyl, a cycloalkyl or an aryl group each having up to 12 carbon atoms and the two radicals R' together optionally represent a --(CH.sub.2).sub.3 -group, by passing 4-oxocarboxylic acids of the form...