The substituted 4H-pyrans are prepared by reacting either aldehydes or ylidene compounds with suitably substituted .beta.-diketones. The substituted 4H-pyrans according to the invention are suitable as active compounds in medicaments, in particular for the treatment of disorders of the central nervous system.

2,2-Dimethyl-3,4-dihydro-2H-benzo[b]pyran-3-ols bearing an amino group in the 4-position and a cyano group in the benzo ring, their salts, esters and ethers, demonstrate excellent vasodilatory activity. The compounds, of which trans-2,2-dimethyl-4-isopropylamino-6-cyano-3,4-dihydro-2H-benzo[b]pyran-3 -ol is a representative embodiment, can be prepared from the corresponding 3,4-epoxy derivative upon treatment with an amine.

1,9-Dihydroxy-3-alkyl-6a,7,8,9,10,10a-hexahydro-6H-dibenzo[b,d]pyrans, useful as hypotensive agents, as psychotropic drugs, particularly as anti-anxiety and/or antidepressant drugs, and as sedative and/or analgesic drugs.

A tetrahydropyran derivative comprising at least three cyclic rings and one aromatic endgroup of the formula A ##STR00001## a process for preparing said tetrahydropyran derivatives, and the use of said tetrahydropyran derivatives as a component in a liquid crystal composition.

Tetrahydropyran derivatives having at least one ester group (--CO--O--) and at least one group --CN, --NCS, ##STR1## --F, --Cl, --OCHF.sub.2, --OCF.sub.3, --CF.sub.3, --OCHFCF.sub.3, --OCF.sub.2 CHFCF.sub.3, SF.sub.5, or --OCF.sub.2 CF.sub.3 ; a process for preparing said tetrahydropyran derivatives, and the use of said tetrahydropyran derivatives as a component in a liquid crystal composition.

There are described new compositions of matter having the following general formula ##SPC1## wherein n is from 0 to 1, wherein one of the R's is selected from the group consisting of fluorine, alkyl, cycloalkyl, aryl, perfluoroalkyl, perfluorocycloalkyl and perfluoroaryl, wherein another one of the R's may be selected from the group consisting of alkyl and perfluoroalkyl, wherein the remaining R's are selected from the group consisting of hydrogen and fluorine, provided that at least one of the ...

Tetrahydro and hexahydro 1-amino-3-alkyl-6H-dibenzo[b,d]pyrans useful as anti-depressant, anti-anxiety, or analgesic agents.

The compounds of this invention are dibenzo[b,d]pyrans having pharmacological activity such as central nervous system activity. A preferred compound is 3-(1,2-dimethylheptyl)-7,8,9,10-tetrahydro-6,6,9-trimethyl-6H-dibenzo[b,d] pyran.

2,2-Dimethyl-3,4-dihydro-2H-benzo[b]pyran-3-ols bearing an amino group in the 4-position and a cyano group in the benzo ring, their salts, esters and ethers, demonstrate excellent vasodilatory activity. The compounds, of which trans-2,2-dimethyl-4-isopropylamino-6-cyano-3,4-dihydro-2H-benzo[b]pyran-3 -ol is a representative embodiment, can be prepared from the corresponding 3,4-epoxy derivative upon treatment with an amine.

A photochromic grey coloring 2H-naphtho[1,2-b]pyran of formula (1) wherein R.sup.1 is selected from mono-, di- or poly-substituted aryl groups, mono-, di- or poly-substituted naphthyl groups and mono-, di- or poly-substituted heteroaryl groups, wherein at least one substituent is a nitrogen containing group, including amino, C.sub.1 -C.sub.20 and C.sub.6 -C.sub.20 alkylamino, C.sub.1 -C.sub.20 and C.sub.6 -C.sub.20 dialkylamino, C.sub.2 -C.sub.20 dialkenylamino, C.sub.2 -C.sub.20 or C.sub.4 -C.s...