To sequence long strands of DNA, cloned strands having lengths longer than 100 bases are, in one embodiment, marked on one end with biotin. These strands are divided into 4 aliquots and each aliquot: (1) is uniquely chemically treated to randomly terminate the strands at the non-biotinylated end at a selected type of base; and (2) is moved continuously by electrophoresis through a different one of four identical channels. In the one embodiment, the strands are randomly terminated at a selected b...

An improved sequencing valve of the type having a valve disk mounted within a valve housing for reciprocating and indexing movement between an inlet port and a plurality of outlet ports to couple a water supply line in sequence with a plurality of outlet conduits in response to turning on and off of a water supply. The valve disk has a flow opening therein which is closed by a spring-biased control valve when the water supply is turned on such that the valve disk is responsive to a relatively lo...

A sequencing valve for use in a pneumatic program controller has two output ports in rotors on a common driving shaft which may be moved intermittently for moving such output ports into line with circles of output ports in stators, in which the rotors are placed. The stator output ports are regularly spaced. The two rotor output ports or the groups of stator ports in the two stators are out of line with each other by half the pitch of the ports in the stators. The intermittent driving motor has ...

A pressure responsive sequencing valve including a housing having an inlet port and a plurality of outlet ports and a ported primary flow control valve located in said housing between said inlet and outlet ports and being mounted for reciprocation between seated and unseated positions and for step-by-step sequencing in rotary motion to place the valve port in register with a selected housing outlet port. An actuation piston is positioned in the housing between said inlet port and the primary val...

A sequencing valve for distributing fluid from an inlet selectively to one or more of a plurality of outlets in response to pressure variation in the source fluid or fluid at other stations within the valve. The valve may be sequenced at the valve or remotely, is compact in construction, is configured to provide anti-siphoning protection, may be easily modified to accomplish several different modes of operation and various sequencing patterns, and is configured for easy maintenance of the variou...

A sequencing valve for distributing fluid from an inlet selectively to one or more of a plurality of outlets. The sequencing valve includes an inlet section, an intermediate section, and an outlet section; a piston valve arrangement controls flow from said inlet section to said intermediate section and a valving member directs flow from said intermediate section into a selected outlet or outlets of said outlet section; said outlet section including a biasing means for biasing said piston arrange...

A flow sequencing valve which employs separate valve elements to generate the force required for cycling and to accomplish discharge port sealing is disclosed. The valve may include an integral pilot solenoid for controlling cycling and is characterized by a force generating element, in the form of a variable resistance to flow, which is free to overtravel relative to the port sealing member whereby flow rate compensation is achieved and water hammer effects eliminated.

A camera for taking a plurality of photographic images utilizing a single focal plane, usually a plate or a sheet of film, which is fixedly disposed with relation to the lens. The camera is divided into a plurality of focal locations arranged about a rotatable mirror associated with the lens and one or more additional mirrors which reflect an image from the rotatable mirror to a portion of the plane. The camera is capable of taking a succession of pictures and displaying them in a tightly packed...

A sequencing timer for providing independently adjustable time intervals of same or different durations starting at the same time or at the end of the preceding interval as applicable. Clock frequency, produced in a clock oscillator, is used to synchronise the incremental charging of one or more capacitors each being part of an adjustable RC timer. Using a relay with multiple, mutually isolated, contacts operated at given clock frequency both high insulation of the timing capacitor and its incre...

An improved flow sequencing and check valve which delivers a single source of fluid to a plurality of outlets. The improvement includes a generally cup-shaped portion which never disengages with the entrance port as it moves the sequencing disc closed in response to a broad range of fluid flow and pressure conditions. The cup-shaped portion is in continuous engagement with the entrance port, allowing virtually all of the fluid to pass through exit ports in the base of the cup-shaped portion and ...