The present invention relates to novel macrocyclic carbonyl compounds of the macrocyclic carbamate and lactone type, to chiral macrocyclic structures, to macrocyclic urea compounds and to macrocyclic thiolactones and to a process for the preparation of same. The process of the invention comprises reacting a stannoxane, silazane or silathiane compound with an activated carbonyl compound in an organic solvent at moderate temperature.

The use of compounds of formula (I) wherein R.sup.1, R.sup.3, R.sup.10, m and Ar are as defined in the Specification and pharmaceutically acceptable salts thereof in the manufacture of a medicament for the treatment or prophylaxis of diseases or conditions in which inhibition of kinase Itk activity is beneficial is disclosed. Certain novel compounds of formula (I), together with processes for their preparation, compositions containing them and their use in therapy are also disclosed ##STR00001##

This invention relates to a method for the novel preparation of 1-adamantanecarboxamides and 1-adamantaneacetamides. Adamantanecarboxamides and adamantaneacetamides are prepared in high yields (80-100%) by treating adamantanecarboxylic acid and adamantaneacetic acid with N,N-diethyl-1,1,2,3,3,3-hexafluoropropylamine, followed by addition of aqueous ammonia or the appropriate amine. The procedure, carried out at ambient temperature using common laboratory equipment, is both convenient and rapid, ...

Two Bacillus species and one Pseudomonas species isolated from soil samples showed good cyclodextrin glycosyltransferase activity, even when grown in simple media. The microorganisms are not pH sensitive and grow well in media containing only starch, a nitrogen source, and minerals. All elaborate the desired enzyme within 4 hours of culturing with growth being complete within about 24 hours.

The use of some glycosaminoglycans like sulodexide, low molecular weight heparin and low molecular weight dermatan sulfate and of the medicines by parenteral use that contain them in the treatment of patients suffering from chronic renal insufficiency subjected to peritoneal dialysis is described. The effectiveness of this use has been shown both by pharmacological studies carried out in nephrectomized rats to whom a peritoneal damage has been caused and by clinical studies carried out in patien...

Bichromal balls have two hemispheres, typically one black and one white, each having different electrical properties. Each ball is enclosed within a spherical shell and then a space between the ball and shell is filled with a liquid to form a microsphere so that the ball is free to rotate in response to an electrical field. The microspheres can then be mixed into a substrate which can be formed into sheets or can be applied to any kind of surface. The result is a film which can form an image fro...

A process for enhancing the functional properties of denatured proteinaceous material of vegetable origin. The enhanced properties include at least one property selected from the group consisting of water absorption, water binding capacity, oil binding capacity, fat binding capacity, and the ability to produce viscous aqueous suspensions. The process includes the steps of obtaining the denatured proteinaceous material by treating undenatured proteinaceous material with aqueous alcohol and mainta...

The invention relates to an arrangement provided with some series-arranged combustion flash bulbs which can be ignited one after the other. According to the invention the succession of the flashes is obtained by choosing the resistive values of heating wires present in the flash bulbs to be unequal prior to flashing, and to have a low resistance of the flashed bulbs.

A method of producing a honeycomb structure of the present invention includes the steps of: forming plugged portions by dipping an end face of a honeycomb structure in slurry in a container, and pressing the honeycomb structure against an inner bottom surface of the container to force the slurry into at least some of the cells; and bringing out the honeycomb structure from the container to obtain the honeycomb structure having at least some of the cells being plugged. An air layer is formed betw...

A semiconductor device includes a semiconductor substrate having a principal plane on which gate, source, and drain electrodes are located. A film made of a polymer with a low dielectric constant is over the gate and drain electrodes to insulate the gate and drain electrodes from the source electrodes. A chip surface electrode located over the low-dielectric-constant polymer film and the source electrode, and connected to ground potential. The source electrode is provided with the ground potenti...