The present invention provides stabilized immunoglobulin molecules that have increased storage stability and/or in vivo half-lives due to the mutation of one or more amino acids that would otherwise render the immunoglobulin molecules susceptible to degradation. In a preferred embodiment, the stabilized immunoglobulins of the invention have mutations at the heavy chain constant domain hinge region. Such stabilized immunoglobulin molecules, i.e., immunoglobulin molecules with increased storage st...

A watercraft including an elongated V-type hull and first and second stabilizers mounted in outrigger fashion on opposite sides of the hull. In a preferred embodiment, each stabilizer includes an elongated flotation member having its longitudinal centerline aligned with the longitudinal centerline of the hull. Each stabilizer is retractably mounted on its respective side of the hull employing a pantographic-type set of extensors interconnecting its flotation member with the hull, whereby each fl...

Isolated polypeptides or polypeptide chains are modified by di-tyrosine cross-linking such that the retain at least one functional activity. In one embodiment, the isolated polypeptide or polypeptide chains comprise at least one di-tyrosine cross-link, wherein at least one tyrosine of the di-tyrosine cross-link originates from a point mutation to tyrosine, and wherein the di-tyrosine cross-linked protein retains at least one function displayed by the protein in the absence of di-tyrosine cross-l...

Isolated polypeptides or polypeptide chains are modified by di-tyrosine cross-linking such that they retain at least one functional activity. In one embodiment, the isolated polypeptide or polypeptide chains comprise at least one di-tyrosine cross-link, wherein at least one tyrosine of the di-tyrosine cross-link originates from a point mutation to tyrosine, and wherein the di-tyrosine cross-linked protein retains at least one function displayed by the protein in the absence of di-tyrosine cross-...

Polychloroethylene, e.g., trichioroethylene and perchloroethylene, is stabilized with a stabilizing amount of a stable free radical stabilizer, e.g., a material having the 2,2,6,6-tetra(lower alkyl)-1-piperidinyloxy-yl free radical group, such as 2,2,6,6-tetramethyl-4-hydroxy-1-piperidinyloxy, or the 2,2,5,5-tetra(lower alkyl)pyrrolidinyloxy group, such as 2,2,5,5-tetramethyl pyrrolidinyloxy. Stable free radical stabilizer is removed from a polychloroethylene composition containing same by conta...

In the method of the invention, hydroxypivalaldehyde (3-hydroxy-2,2-dimethylpropanal) and/or its dimer is stored under solid conditions containing an amount of water. By storing such solid conditions, hydroxypivalaldehyde and/or its dimer is stored for a long period of time without reducing its purity.

Dentifrice containing flavoring oil and phosphate ion and 1,6-di-(p-chlorophenyl biguanidohexane) and ethanol to stabilize the dentifrice against separation.

A camera has camera optics and an optics support (3) which is rotatably journalled in a camera housing (5) and includes the camera optics. The camera optics include a first pivot mirror (7) at the input end and a second pivot mirror (11). The first pivot mirror (7) is pivotable about a first pivot axis (9) relative to the optics support (3). The optics support (3) is rotatable relative to the camera housing (5) about a rotational axis (9) parallel to a first pivot axis (9). Furthermore, the seco...

Spandex-type polyurethanes are protected against mechanical diagradation and yellowing which is produced by nitrogen oxide, chlorine or UV light, by incorporation of poly (N,N-diethyl-2-aminoethyl methacrylate) and either zinc oxide or an admixture of huntite and hydromagnesite.

The present invention disclose a method comprising the steps of fixing a first device to a first housing using a first manufacturing process and fixing a second device to a first housing using a second manufacturing process. The first device can be a laser and the second device an optical fiber. After the first and second device have been fixed to the first housing, the first device lies at a first position relative to the second device. The first device, the second device, and the first housing...