Steroids of the formula ##STR1## wherein R.sup.1 to R.sup.4, X and n have the significance given in the description, which lower the intestinal resorption of cholesterol and plasma cholesterol and a process of making same from corresponding steroids having an alcohol residue of the formula --O--X--OH in the 3-position.

A compound of the formula ##STR1## wherein R is selected from the group consisting of hydrogen, ##STR2## alkyl and alkoxy of 1 to 12 carbon atoms, aryl and aryloxy of 6 to 12 carbon atoms and aralkyl and aralkoxy of 7 to 12 carbon atoms, R.sub.1 and R.sub.2 are individually alkyl of 1 to 6 carbon atoms or taken together with the nitrogen atom to which they are attached form a 5 or 6 membered heterocycle optionally containing a second heteroatom of --S--, --O-- or --N--, R.sub.A is selected from ...

Novel 9.alpha.,11.beta.-dichloro-16.alpha.-methyl-.DELTA..sup.1,4 -pregnadiene 3,20-diones of the formula ##STR1## wherein R is selected from the group consisting of trimethylsilylphenyl, cyclododecyloxy, dicyclopentylmethoxy and cyclohexylmethoxy having a suprising "in loco" anti-inflammatory activity limited to place of inflammation without systemic effects and a process for their preparation.

Novel 19-nor steroids and 19-nor-D-homo-steroids of the formula ##STR1## wherein R.sub.1 is an organic radical of 1 to 18 carbons atoms containing at least one atom selected from the group consisting of nitrogen, phosphorous and silicon with the atom immediately adjacent to the 11-carbon atom being carbon, R.sub.2 is a hydrocarbon of 1 to 8 carbon atoms, X is selected from the group consisting of a pentagonal ring and a hexagonal ring optionally substituted and optionally containing a double bon...

Novel 3-amino-steroids of the formula ##STR1## wherein R.sub.1 is selected from the group consisting of hydrogen and methyl, W is selected from the group consisting of hydrogen and --OH and taken together with x forms ethylidene, X is selected from the group consisting of ethyl, ##STR2## and taken together with W forms ethylidene and the wavy lines signify that the substituents are in the .alpha. or .beta.-position with the proviso that when R.sub.1 is methyl and X is ethyl, ##STR3## W is --OH a...

Methods and compositions for preventing and treating neovascularization with steroids is disclosed.

7.alpha.-acylthio-9.alpha.,11.alpha.-epoxy-20-spirox-4-ene-3,21-diones of the formula I ##STR1## in which R represents lower alkanoyl and --A--A-- represents an ethylene or cyclopropylene group, have a high aldosterone-antagonistic activity without significant sexually-specific side-effects and can be used as potassium-protecting diuretics in the treatment of various forms of hyperaldosteronism. The compounds can be obtained by conventional processes of steroid chemistry.

This invention relates to .alpha.-glucosides of steroids containing hydroxy groups in both the 16.alpha.- and 17-positions and the method for preparing them by reacting with a polysaccharide or an oligosaccharide, such as maltose, in the presence of a source of the enzyme: amylase or transglucosylase. The .alpha.-glucosides are new compounds that possess estrogenic activity. They may be used, therefore, as antifertility agents.

A novel process for the preparation of 20-keto-pregnanes.

Disclosed are amino substituted steroids (XI) which contain an imidazolylpiperazinyl group attached to the terminal carbon atom of the C.sub.17 -side chain which are useful as pharmaceutical agents for treating a number of conditions.