A diuretic pharmaceutically acceptable solution of triamterene and solutions of triamterene and hydrochlorothiazide to provide an antihypertensive and diuretic effect for those in need thereof. Triamterene is solubilized in a combination of a glycol and lactic acid present in an amount sufficient to maintain the triamterene in solution. A pharmaceutically acceptable diluent, such as glycerin is also present.

A sterile, non-irritant, non-toxic aqueous solution adapted for topical administration to the eye which contains 2,4,7-triamino-6-phenylpteridine rendered soluble by a solubilizing amount of a xanthine derivative. The composition may be used to treat ocular hypertension and glaucoma.

The invention provides novel aldehyde adducts of triamterene having improved solubility and bioavailability as compared to triamterene. Pharmaceutical compositions containing the novel adducts and having diuretic activity are also described.

A sterile, non-irritant, non-toxic pharmaceutical composition adapted for topical administration to the eye which contains 2,4,7-triamino-6-phenylpteridine is described. The composition may be used to treat ocular hypertension and glaucoma.

A combination pharmaceutical composition is described, together with the process for manufacturing said pharmaceutical composition wherein the active ingredients, namely triamterene and hydrochlorothiazide, are incorporated into a solid dosage form via a single wet granulation process utilizing an acid component. Said process simplifies the formulation and manufacturing, permits greater uniformity, and increases in vitro dissolution.

Pharmaceutical composition containing 1 part by weight of xipamide and 3-4 parts by weight of triamterene, for diuretic and antihypertensive treatment.

A gelatin capsule unit dosage form containing triamterene, 2,4,7-triamino-6-phenylpteridine, which results in rapid dissolution of the active ingredient. The dosage form comprises the addition of a combination of a surfactant and a carbonate or bicarbonate salt as diluents.

A gelatin capsule dosage form containing triamterene, 2,4,7-triamino-6-phenylpteridine, which results in rapid dissolution of the active ingredient. The dosage form comprises the pharmaceutical binder methylcellulose in combination with low doses of a surfactant or a carbonate salt as disintegrants.