The invention relates to a controlled release dosage form comprising three actives: acetaminophen, pseudoephedrine sulfate and dexbrompheniramine maleate.

The invention relates to a controlled release dosage form comprising three actives: acetaminophen, psueudoephedrine sulfate and dexbrompheniramine maleate.

Chewable tablets comprising individual taste-masked coated granules comprising an analgesic and at least one water soluble medicament and methods of producing the same are described.

A controlled release tablet for oral administration is disclosed which has a tablet core including an insoluble therapeutically active agent having an aqueous solubility of less than or equal to about 5 mg/ml in a sufficient amount to render a therapeutic effect. The core provides rapid release of said therapeutically active agent upon exposure to aqueous solutions. The tablet core is coated with a controlled release coating permitting sustained release of said therapeutically active agent when ...

A directly compressible ultra fine acetaminophen granulation composition capable of being directly compressed into an acetaminophen tablet comprises from about 85 to about 95 wt % acetaminophen, from about 1 to about 4 wt % essentially water-insoluble tablet/capsule disintegrant, from about 0.5 to about 5.0 wt % polyvinylpyrrolidone, from about 0.5 to about 5.0 wt % totally pregelatinized starch, about 0.25 to about 3.0 wt % of a fluidizing agent, from about 0.25 to about 3.0 wt % of a lubricant...

A method for preventing and/or reducing the toxicity of acetaminophen is disclosed. An amount of grape seed proanthocyanidin extract effective to inhibit toxicity of acetaminophen is administered before, simultaneous with, and/or after dosage of acetaminophen. This allows for increased therapeutic dosages of acetaminophen to be administered with reduced risk of toxic effects, and for prevention of toxic effects in people with special sensitivity to acetaminophen. A composition containing both ac...

The invention relates to a controlled release dosage form comprising three actives: acetaminophen, pseudoephedrine and dexbrompheniramine.

The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter ligands, i.e., acetaminophen, ranitidine, strychnine and denatonium. The present invention further relates to the use of these receptors in assays for identifying ligands that modulate the activation of these taste receptors and which may be used as additives in foods, beverages and medicinals for modifying (blocking) T2R-associated bitter taste.

Disclosed are an acetaminophen composition containing a minor amount of a pheniramine maleate, a spray-drying method for preparing the composition and orally administerable analgesic antihistaminic tablets formed from the composition.

Unexpectedly enhanced relief of pain in a mammal is obtained by oral administration of a composition consisting essentially of zomepirac or a pharmaceutically suitable salt thereof and acetaminophen.