This invention provides a series of novel hydroxamic acids of formula I which are useful as inhibitors of metalloproteases such as endopeptidases.

The present invention relates to cinnamohydroxamic acids. These compounds inhibit 5-lipoxygenase and are useful as bronchodilators.

The invention concerns novel 1,3-dioxane alkenoic acid derivatives of the formula I ##STR1## wherein: n is the integer 1 or 2; Y is methyleneoxy, vinylene or ethylene; A.sup.1 is (1-6C)alkylene; R.sup.1 is a group of the formula R.sup.2.A.sup.2 --, in which: R.sup.2 is phenyl unsubstituted or bearing up to three substituents which are independently selected from (1-6C)alkyl, (1-6C)alkoxy, (2-6C)alkanoyl, (1-6C)alkylthio, (1-6C)alkylsulphonyl, halogeno, trifluoromethyl, nitro and cyano; A.sup.2 i...

Araliphatylaminoalkanediphosphonic acids of formula ##STR1## wherein R.sub.1 is an aromatically substituted aliphatic radical, R.sub.2 is hydrogen or a monovalent aliphatic radical and alk is a divalent aliphatic radical, and their salts, exhibit a pronounced regulatory action on the calcium metabolism and can be used as medicaments for the treatment of diseases that are attributable to calcium metabolsim disorders. They are prepared, for example, by reacting a compound of formula ##STR2## where...

Phenylaliphatylaminoalkanediphosphonic acids of the formula ##STR1## in which R.sub.1 is an aliphatic hydrocarbon radical having 4 and not more than 7 C atoms and substituted by phenyl, R.sub.2 is a monovalent aliphatic hydrocarbon radical having 1 and not more than 4 C atoms and alk is a divalent aliphatic hydrocarbon radical having 2 and not more than 4 C atoms, and their salts, have a particularly pronounced regulating action on calcium metabolism and can be used as medicaments for the treatm...

Aminobenzophenones have the formula ##STR1## where the ring A may be benzofused, X.sup.1 is hydrogen or hydroxysulfonyl, X.sup.2 is hydrogen, hydroxysulfonyl, hydroxysulfonylphenyl, hydroxysulfonylbenzyl or hydroxysulfonylphenylethyl, R.sup.1, R.sup.2 and R.sup.3 are each independently of the others hydrogen, halogen, C.sub.1 -C.sub.12 -alkyl, cyclohexyl or C.sub.1 -C.sub.4 -alkoxy, or one of them may also be the radical of the formula ##STR2## where L is a chemical bond, C.sub.1 -C.sub.4 -alkyl...

Sulfimidoperoxycarboxylic acids of the formula ##STR1## in which A is a group of the formula ##STR2## n is the number 0, 1 or 2, R.sup.1 is hydrogen, fluorine, chlorine, bromine, C.sub.1 -C.sub.20 - alkyl, C.sub.2 -C.sub.20 -alkenyl, aryl or C.sub.1 -C.sub.10 -alkylaryl, R.sup.2 is hydrogen, fluorine, chlorine, bromine or a group of the formula SO.sub.3 M, CO.sub.2 M or OSO.sub.3 M, M is hydrogen, an alkali metal or ammonium ion or the stoichiometric amount of an alkaline earth metal ion and X i...

Glycosiduronic acids, such as alkyl glycosiduronic acids or alkenyl glycosiduronic acids, which may be used in the preparation of surfactant compositions, such as detergents and cleansers, are prepared by reacting an oxidized mono-, oligo-, or polysaccharide with up to 10 monomer units with one or more fatty alcohols having 8-22 carbon atoms in the presence of a catalyst, preferably in bulk, and after acetalization removing the excess alcohol. Preferably the oxidized mono-saccharide used is gluc...

This invention provides novel compositions comprising aryl phosphonic or phosphinic acids substituted with more than one sulfo radical. These novel compounds may be reacted with tetravalent metal ions to provide polymers having an inorganic backbone, which polymers are useful as acid catalysts.

New compounds are described that are 2-(hydroxy substituted-4-biphenylyl)propionic acids. Processes of making and using them and pharmaceutical compositions containing them are also described. The compounds have, inter alia, antiinflammatory activity.